Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4231654 | 0.89 | LMNA (0.42) | LMNAKDM4EGAATSHRHTT | |
| SCHEMBL27889099 | 0.73 | LMNA (0.47) | LMNAKDM4EGAAKLK6 | |
| SCHEMBL2876400 | 0.72 | NR4A2 (0.59) | LMNAKDM4EGAANR4A2TSHR | |
| SCHEMBL7832340 | 0.70 | TSHR (0.48) | LMNAGAANR4A2TSHRMAPT | |
| SCHEMBL31429079 | 0.69 | SMN1; SMN2 (0.41) | LMNAKDM4EGAAMAPTMEN1 | |
| SCHEMBL14865005 | 0.69 | ALOX5 (0.56) | LMNAKDM4EGAAHPGD | |
| SCHEMBL8296306 | 0.69 | PRSS1 (0.55) | LMNAKDM4EGAAMAPTMEN1 | |
| SCHEMBL1429298 | 0.68 | AKR1B1 (0.55) | LMNAKDM4EHTTMAPTMEN1 | |
| SCHEMBL7669841 | 0.68 | NLRP3 (0.48) | LMNAKDM4EHTTMAPTSMN1; SMN2 | |
| SCHEMBL11331437 | 0.68 | KDM4E (0.49) | LMNAKDM4EGAAMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2075249-B1 | Indolylmaleimide derivatives | NOVARTIS AG (CH) | 2012-03-28 | — | — | EP | disclosed |
| EP-2075249-A2 | Indolylmaleimide derivatives | Novartis AG (CH) | 2009-07-01 | — | — | EP | disclosed |