Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 2/20 | 0.33 |
| ▸ | PPARA | Q07869 | 2/20 | 0.33 |
| ▸ | DHODH | Q02127 | 3/20 | 0.32 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.32 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 3/20 | 0.31 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.31 |
| ▸ | DRD3 | P35462 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8566943 | 1.00 | PPARD (0.33) | PPARDPPARADHODHDGAT1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL8561696 | 0.89 | ACHE (0.39) | PPARDPPARADHODHALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL8564010 | 0.88 | DRD2 (0.34) | PPARDPPARAACHEDRD3DRD2 | |
| SCHEMBL7469952 | 0.83 | L3MBTL1 (0.36) | DGAT1ALDH1A1LMNAL3MBTL1MAPT | |
| Hydrochloric Acid SCHEMBL7469837 | 0.82 | L3MBTL1 (0.35) | DGAT1ALDH1A1LMNAL3MBTL1MAPT | |
| Hydrochloric Acid SCHEMBL8569741 | 0.81 | DGAT1 (0.32) | DGAT1PTGER3PTGER2ACHEMCHR1 | |
| SCHEMBL8558376 | 0.80 | ESR1 (0.38) | PPARDPPARADHODHPOLB | |
| SCHEMBL8563986 | 0.80 | ESR1 (0.38) | PPARDPPARADHODHPOLB | |
| SCHEMBL7392878 | 0.79 | ITGB3 (0.40) | DGAT1 | |
| SCHEMBL7398264 | 0.79 | ITGB3 (0.40) | DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612741-B1 | Cyclic derivatives, medicaments containing them and process for their preparation | THOMAE GMBH DR K (DE) | 1998-06-10 | — | — | EP | disclosed |
| EP-0612741-A1 | Cyclic derivatives, medicaments containing them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1994-08-31 | — | — | EP | disclosed |