Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.49 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.48 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.48 |
| ▸ | KDM1A | O60341 | 6/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.47 |
| ▸ | CCNK | O75909 | 1/20 | 0.46 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.46 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.45 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.45 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.45 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.45 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8719948 | 0.84 | KDM1A (0.49) | SLC6A7KDM1ASIGMAR1EPHX2ALDH1A1 | |
| SCHEMBL8407569 | 0.84 | CCNK (0.51) | SLC6A7KDM1ASIGMAR1EPHX2ALDH1A1 | |
| SCHEMBL8410754 | 0.82 | ITGB3 (0.54) | L3MBTL3 | |
| SCHEMBL8430024 | 0.80 | ALDH1A1 (0.56) | SLC6A7KDM1ASIGMAR1EPHX2ALDH1A1 | |
| SCHEMBL8408016 | 0.79 | SLC6A7 (0.51) | SLC6A7MKNK1MKNK2KDM1ASIGMAR1 | |
| SCHEMBL16627283 | 0.77 | L3MBTL3 (0.77) | SLC6A7MKNK1MKNK2KDM1AEPHX2 | |
| SCHEMBL8560134 | 0.77 | KDM1A (0.49) | KDM1AEPHX2ALDH1A1EGLN1CCNK | |
| SCHEMBL8244983 | 0.77 | ALDH1A1 (0.56) | SLC6A7KDM1ASIGMAR1EPHX2ALDH1A1 | |
| SCHEMBL13503971 | 0.76 | GRM5 (0.69) | KDM1AEPHX2ALDH1A1L3MBTL3PDK1 | |
| SCHEMBL28849726 | 0.73 | EPHX2 (0.51) | SLC6A7KDM1ASIGMAR1EPHX2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5922763-A | ANTICOAGULANT; CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1999-07-13 | — | — | US | disclosed |
| US-5736559-A | CARDIOVASCULAR DISORDERS; RESPIRATORY SYSTEM DISORDERS | KARL THOMAE GMBH (DE) | 1998-04-07 | — | — | US | disclosed |
| US-5597825-A | AGGREGATION INHIBITORS | DR. KARL THOMAE GMBH (DE) | 1997-01-28 | — | — | US | disclosed |
| EP-0496378-B1 | Biphenylderivatives, drugs containing these compounds and processes for their preparation | THOMAE GMBH DR K (DE) | 1995-09-20 | — | — | EP | disclosed |
| EP-0496378-A1 | Biphenylderivatives, drugs containing these compounds and processes for their preparation | Dr. Karl Thomae GmbH (DE) | 1992-07-29 | — | — | EP | disclosed |