Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.36 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.35 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8568966 | 0.76 | SMN1; SMN2 (0.44) | SMN1; SMN2MEN1KMT2AKDM4ELMNA | |
| SCHEMBL8573164 | 0.72 | GPBAR1 (0.45) | TACR1SMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL8570467 | 0.71 | L3MBTL1 (0.49) | TACR1SMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL8571115 | 0.70 | PDE4D (0.53) | SMN1; SMN2MEN1KMT2AKDM4EPDE4D | |
| SCHEMBL8574909 | 0.69 | TACR1 (0.43) | TACR1SMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL8720338 | 0.69 | TACR1 (0.57) | TACR1SMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL5883327 | 0.68 | TACR1 (0.54) | TACR1SMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL7452209 | 0.68 | TACR1 (0.46) | TACR1SMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL8569426 | 0.67 | TACR1 (0.42) | TACR1SMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL8574900 | 0.67 | TACR1 (0.42) | TACR1SMN1; SMN2MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5846990-A | Substituted biphenyl isoxazole sulfonamides | BRISTOL-MYERS SQUIBB CO. (US) | 1998-12-08 | — | — | US | claimed |
| US-5846990-A | Substituted biphenyl isoxazole sulfonamides | BRISTOL-MYERS SQUIBB CO. (US) | 1998-12-08 | — | — | US | disclosed |