Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HSD17B1 | P14061 | 4/20 | 0.41 |
| ▸ | HSD17B2 | P37059 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TACR1 | P25103 | 2/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | MYC | P01106 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8573485 | 0.91 | MEN1 (0.42) | MEN1KMT2ASMN1; SMN2HTTHSD17B1 | |
| SCHEMBL8570522 | 0.83 | NPC1 (0.46) | MEN1KMT2ASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL8573577 | 0.78 | TSHR (0.43) | MEN1KMT2ASMN1; SMN2ALDH1A1TACR1 | |
| SCHEMBL8818021 | 0.76 | CHRNB2 (0.43) | MEN1KMT2ASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL8569633 | 0.75 | MEN1 (0.64) | MEN1KMT2ASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL8567759 | 0.75 | NPSR1 (0.43) | MEN1KMT2ASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL17207224 | 0.75 | ALDH1A1 (0.46) | MEN1KMT2ASMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL8818040 | 0.74 | LTB4R (0.42) | KMT2AHTTHSD17B1HSD17B2ALDH1A1 | |
| SCHEMBL12495722 | 0.73 | HSD17B2 (0.59) | HSD17B1HSD17B2KDM4EGAAGPBAR1 | |
| SCHEMBL8818195 | 0.73 | RXFP1 (0.46) | MEN1KMT2ASMN1; SMN2HTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5846990-A | Substituted biphenyl isoxazole sulfonamides | BRISTOL-MYERS SQUIBB CO. (US) | 1998-12-08 | — | — | US | disclosed |