Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.69 |
| ▸ | HPGD | P15428 | 4/20 | 0.69 |
| ▸ | MEN1 | O00255 | 4/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.69 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.69 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | GAA | P10253 | 5/20 | 0.52 |
| ▸ | SLC5A1 | P13866 | 2/20 | 0.51 |
| ▸ | SLC5A2 | P31639 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.50 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27697248 | 0.85 | MAPT (0.60) | MAPTHPGDMEN1KMT2APIK3CA | |
| SCHEMBL454742 | 0.84 | SLC5A1 (0.69) | MAPTHPGDMEN1KMT2APIK3CA | |
| SCHEMBL145265 | 0.81 | LMNA (0.78) | MAPTHPGDMEN1KMT2APIK3CA | |
| SCHEMBL8578359 | 0.81 | MAPT (0.55) | MAPTHPGDMEN1KMT2APIK3CA | |
| SCHEMBL15869780 | 0.78 | L3MBTL1 (0.65) | MAPTHPGDMEN1KMT2APIK3CA | |
| SCHEMBL10562315 | 0.77 | PIK3CA (0.70) | MAPTHPGDMEN1KMT2APIK3CA | |
| SCHEMBL10563951 | 0.76 | PIK3CA (1.00) | MAPTHPGDMEN1KMT2APIK3CA | |
| SCHEMBL24841623 | 0.76 | CYP19A1 (0.70) | MAPTHPGDMEN1KMT2APIK3CA | |
| SCHEMBL5036945 | 0.75 | MAPT (0.77) | MAPTHPGDMEN1KMT2APIK3CA | |
| SCHEMBL11172110 | 0.75 | CTBP2 (0.62) | HPGDMEN1KMT2APIK3CACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998017662-A1 | PHENYL-SUBSTITUTED BICYCLIC HETEROCYCLYL DERIVATIVES AND THEIR USE | NOVARTIS AG (CH) | 1998-04-30 | — | — | WO | disclosed |