Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HCN1 | O60741 | 1/20 | 0.35 |
| ▸ | HCN4 | Q9Y3Q4 | 1/20 | 0.35 |
| ▸ | BDKRB1 | P46663 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8413812 | 0.90 | KDM4E (0.39) | LMNAKDM4EALDH1A1BDKRB1 | |
| SCHEMBL8415391 | 0.90 | NPC1 (0.38) | LMNAKDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL8575563 | 0.83 | LMNA (0.41) | LMNAKDM4EALDH1A1RAB9AKMT2A | |
| SCHEMBL8417064 | 0.79 | ITGB3 (0.43) | LMNAKDM4EALDH1A1 | |
| SCHEMBL8413814 | 0.73 | HRH3 (0.46) | RAB9AKMT2A | |
| SCHEMBL8415393 | 0.72 | DPP4 (0.40) | LMNAALDH1A1RAB9AKMT2AOPRM1 | |
| SCHEMBL7275623 | 0.65 | HDAC8 (0.41) | LMNAALDH1A1OPRM1OPRD1 | |
| SCHEMBL8575284 | 0.64 | HRH3 (0.41) | ALDH1A1 | |
| SCHEMBL12062474 | 0.63 | CA1 (0.49) | ALDH1A1KMT2AKDM5B | |
| SCHEMBL27564119 | 0.61 | ALDH1A1 (0.59) | LMNAKDM4EALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5852192-A | Cyclic urea derivatives, pharmaceutical compositions containing these compounds and processes for preparing them | DR. KARL THOMAE GMBH (DE) | 1998-12-22 | — | — | US | disclosed |