Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | CHKA | P35790 | 1/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.42 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.42 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | USP19 | O94966 | 1/20 | 0.35 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.34 |
| ▸ | VNN1 | O95497 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | TACR1 | P25103 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8575754 | 1.00 | CA2 (0.47) | CA2CHKACHRNB2CHRNA3CHRNA4 | |
| SCHEMBL18855618 | 0.86 | ALDH1A1 (0.43) | CA2CHKANAMPTUSP19RIPK1 | |
| SCHEMBL27889764 | 0.84 | NAMPT (0.41) | NAMPTUSP19SCD5VNN1RIPK1 | |
| SCHEMBL27873480 | 0.84 | NAMPT (0.41) | NAMPTUSP19SCD5VNN1RIPK1 | |
| SCHEMBL4780190 | 0.84 | NAMPT (0.41) | NAMPTUSP19SCD5VNN1RIPK1 | |
| SCHEMBL4772640 | 0.78 | NAMPT (0.37) | CA2NAMPTCA12CA1CA9 | |
| SCHEMBL8520605 | 0.76 | CA2 (0.50) | CA2CHKACHRNB2CHRNA3CHRNA4 | |
| SCHEMBL2830943 | 0.74 | NAMPT (0.40) | NAMPTSCD5VNN1RIPK1POLB | |
| SCHEMBL18686787 | 0.73 | SCD5 (0.40) | NAMPTSCD5VNN1RIPK1POLB | |
| SCHEMBL22468655 | 0.73 | NAMPT (0.39) | NAMPTSCD5VNN1RIPK1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012068450-A1 | CYCLOBUTYL SUBSTITUTED PYRROLOPYRIDINE AND PYRROLOPYRIMIDINE DERIVATIVES AS JAK INHIBITORS | INCYTE CORPORATION (US) | 2012-05-24 | — | — | WO | disclosed |