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Arginine

Arginine

SCHEMBL8587129

C[C@@H](O)[C@H](N)C(=O)OC(=O)[C@@H]1CCCN1.N=C(N)NCCC[C@H](N)C(=O)O.NC(=O)CC[C@H](N)C(=O)O.N[C@@H](CO)C(=O)O

nearest known ligand 0.31

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACE

The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ ALOX15 P16050 1/20 0.31
▸ BLM P54132 1/20 0.31
▸ PMP22 Q01453 1/20 0.31
▸ KMT2A Q03164 1/20 0.31
▸ PRCP P42785 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Arginine SCHEMBL8587127 0.88 ALOX15 (0.33) ALOX15BLMPMP22KMT2APRCP
Glutamine SCHEMBL5702894 0.86 KEAP1 (0.31) —
Glutamic Acid SCHEMBL7067346 0.83 GRM8 (0.37) —
Serine SCHEMBL18428172 0.82 ELANE (0.31) KMT2A
Arginine SCHEMBL4223569 0.82 PRCP (0.33) ALOX15BLMPMP22KMT2APRCP
Arginine SCHEMBL28755791 0.81 ALOX15 (0.35) ALOX15BLMPMP22KMT2APRCP
Arginine SCHEMBL16581528 0.81 ALOX15 (0.41) ALOX15BLMPMP22KMT2APRCP
Arginine SCHEMBL29141605 0.80 KDM1A (0.34) ALOX15BLMPMP22KMT2APRCP
Leucine SCHEMBL7037614 0.80 PRCP (0.31) PRCP
Arginine SCHEMBL27801173 0.80 PRCP (0.30) PRCP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0877811-A1 MUTATED PRENYL DIPHOSPHATE SYNTHASES Toyota Jidosha Kabushiki Kaisha (JP) 1998-11-18 — — EP disclosed
WO-1998020138-A1 MUTATED PRENYL DIPHOSPHATE SYNTHASES TOYOTA JIDOSHA KABUSHIKI KAISHA (JP) 1998-05-14 — — WO disclosed