Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.62 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.47 |
| ▸ | DCLRE1B | Q9H816 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | PGR | P06401 | 7/20 | 0.42 |
| ▸ | MGAM | O43451 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SI | P14410 | 1/20 | 0.41 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21363768 | 0.82 | ESR2 (0.69) | ESR2ALOX5TAAR1MAOBPGR | |
| SCHEMBL1695904 | 0.81 | ALDH1A1 (0.48) | ESR2 | |
| SCHEMBL25523526 | 0.79 | HSD17B1 (0.42) | ESR2ALOX5DCLRE1BGAA | |
| SCHEMBL31514000 | 0.77 | — | — | |
| SCHEMBL696635 | 0.77 | — | — | |
| SCHEMBL16394285 | 0.76 | TAAR1 (0.71) | ESR2ALOX5TAAR1MAOBPGR | |
| SCHEMBL31491189 | 0.76 | TAAR1 (0.71) | ESR2ALOX5TAAR1MAOBPGR | |
| SCHEMBL817554 | 0.76 | ALOX5 (0.65) | ESR2ALOX5TAAR1MAOBPGR | |
| SCHEMBL31222672 | 0.76 | ALOX5 (0.65) | ESR2ALOX5TAAR1MAOBPGR | |
| SCHEMBL3793227 | 0.75 | ESR2 (0.60) | ESR2ALOX5TAAR1MAOBPGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0880504-A1 | HETEROCYCLO-SUBSTITUTED IMIDAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997027181-A1 | HETEROCYCLO-SUBSTITUTED IMIDAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-07-31 | — | — | WO | disclosed |