SCHEMBL8599743

SCHEMBL8599743

CCCCOC(=O)C(CC)NC(=O)Cc1ccc(Cl)c(Cl)c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA2 P00918 2/20 0.46
CA1 P00915 1/20 0.46
SMN1; SMN2 Q16637 4/20 0.45
CYP1A2 P05177 3/20 0.45
CYP2D6 P10635 2/20 0.45
KDM4E B2RXH2 1/20 0.45
PDE4A P27815 1/20 0.45
HIF1A Q16665 1/20 0.45
HDAC10 Q969S8 1/20 0.45
HDAC6 Q9UBN7 1/20 0.45
TSHR P16473 3/20 0.43
TACR1 P25103 1/20 0.43
CSNK1D P48730 2/20 0.43
LMNA P02545 2/20 0.41
ALDH1A1 P00352 1/20 0.41
EPHX2 P34913 1/20 0.41
S1PR3 Q99500 1/20 0.41
L3MBTL1 Q9Y468 2/20 0.40
MEN1 O00255 1/20 0.40
MAPT P10636 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7576943 0.88 CNR2 (0.51) SMN1; SMN2CYP1A2CYP2D6KDM4EPDE4A
SCHEMBL4413017 0.84 SMN1; SMN2 (0.44) SMN1; SMN2TSHRTACR1CSNK1DLMNA
SCHEMBL7567337 0.83 ELANE (0.48) SMN1; SMN2CYP1A2CYP2D6KDM4EPDE4A
SCHEMBL7569870 0.82 TDP1 (0.58) SMN1; SMN2CYP1A2CYP2D6KDM4EPDE4A
SCHEMBL7571115 0.82 KMT2A (0.54) SMN1; SMN2CYP1A2CYP2D6KDM4EPDE4A
SCHEMBL7573224 0.82 CNR2 (0.58) SMN1; SMN2CYP1A2CYP2D6KDM4EPDE4A
SCHEMBL6136678 0.80 S1PR3 (0.48) CA2CA1SMN1; SMN2TSHRLMNA
SCHEMBL7571824 0.80 EPHX2 (0.51) ALDH1A1EPHX2RAB9A
SCHEMBL7571045 0.80 GLS (0.45) SMN1; SMN2CYP1A2CYP2D6KDM4EPDE4A
SCHEMBL7574286 0.80 CNR2 (0.46) SMN1; SMN2CYP1A2CYP2D6KDM4EPDE4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0951464-A1 N-(ARYL/HETEROARYLACETYL) AMINO ACID ESTERS, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING BETA-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS Elan Pharmaceuticals, Inc. (US) 1999-10-27 EP claimed
WO-1998022430-A9 N-(ARYL/HETEROARYLACETYL) AMINO ACID ESTERS, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING b-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS 1998-08-20 WO claimed
WO-1998022430-A1 N-(ARYL/HETEROARYLACETYL) AMINO ACID ESTERS, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING b-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS ELAN PHARMACEUTICALS, INC. (US) 1998-05-28 WO claimed