Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.44 |
| ▸ | PLK1 | P53350 | 4/20 | 0.42 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28624569 | 0.72 | SMN1; SMN2 (0.54) | NR4A2ALDH1A1KMT2APOLBMEN1 | |
| SCHEMBL535878 | 0.71 | POLB (0.72) | NR4A2ALDH1A1KMT2AKDM4EPOLB | |
| SCHEMBL29965768 | 0.71 | POLB (0.72) | NR4A2ALDH1A1KMT2AKDM4EPOLB | |
| SCHEMBL12168490 | 0.71 | MAPT (0.57) | PLK1ALDH1A1KMT2AKDM4EPOLB | |
| SCHEMBL2082208 | 0.70 | CA12 (0.52) | AKR1C3AKR1C1PLK1ALDH1A1KMT2A | |
| SCHEMBL28087228 | 0.70 | LMNA (0.55) | KDM4ELMNA | |
| SCHEMBL8836604 | 0.70 | FABP4 (0.51) | ALDH1A1KMT2AKDM4EPOLBMEN1 | |
| Hydrochloric Acid SCHEMBL2434452 | 0.69 | POLB (0.70) | NR4A2ALDH1A1KMT2APOLBMEN1 | |
| SCHEMBL7778085 | 0.69 | PLK1 (0.46) | AKR1C3AKR1C1PLK1ALDH1A1KMT2A | |
| SCHEMBL14118735 | 0.69 | ALDH1A1 (0.50) | AKR1C3AKR1C1PLK1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0821685-A1 | INDOLE-3-CARBONYL AND INDOLE-3-SULFONYL DERIVATIVES AS PLATELET ACTIVATING FACTOR ANTAGONISTS | ABBOTT LABORATORIES (US) | 1998-02-04 | — | — | EP | disclosed |