SCHEMBL861300

SCHEMBL861300

Nc1nc2ccc(Cc3ccccc3)cc2c2ccccc12

nearest known ligand 0.46

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.45
CYP3A4 P08684 1/20 0.45
CYP2C19 P33261 1/20 0.45
HIF1A Q16665 1/20 0.45
APP P05067 2/20 0.44
DHFR P00374 1/20 0.42
ABCB1 P08183 1/20 0.42
DCPS Q96C86 1/20 0.42
IDH1 O75874 1/20 0.41
LTA4H P09960 1/20 0.41
ADORA2A P29274 1/20 0.40
ADORA1 P30542 1/20 0.40
TLR8 Q9NR97 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5355383 0.83 DHFR (0.60) DHFRDCPS
SCHEMBL861436 0.80 APP (0.43) APPDCPSTLR8
SCHEMBL840409 0.78 TLR8 (0.51) TLR8
SCHEMBL38660782 0.77 GPR3 (0.52) KDM4ECYP3A4CYP2C19HIF1AIDH1
SCHEMBL21065256 0.77 APP (0.38) APPDHFRDCPSTLR8
SCHEMBL841210 0.76 TLR8 (0.54) TLR8
SCHEMBL861205 0.74 CYP1A1 (0.50) KDM4EAPPDCPSADORA2A
SCHEMBL72673 0.74 KDM4E (0.47) KDM4EAPPDCPSADORA2A
SCHEMBL16767246 0.74 HTT (0.59) APPDCPSADORA2AADORA1
SCHEMBL72801 0.73 DCPS (0.64) KDM4EHIF1AAPPDCPSADORA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8142909-B2 Blue phosphorescent imidazophenanthridine materials UNIVERSAL DISPLAY CORPORATION (US) 2012-03-27 US disclosed
US-8142909-B2 Blue phosphorescent imidazophenanthridine materials UNIVERSAL DISPLAY CORPORATION (US) 2012-03-27 US disclosed
WO-2008156879-A1 BLUE PHOSPHORESCENT IMIDAZOPHENANTHRIDINE MATERIALS UNIVERSAL DISPLAY CORPORATION (US) 2008-12-24 WO disclosed
US-20080297033-A1 BLUE PHOSPHORESCENT IMIDAZOPHENANTHRIDINE MATERIALS UNIVERSAL DISPLAY CORPORATION 2008-12-04 US disclosed
US-20080297033-A1 BLUE PHOSPHORESCENT IMIDAZOPHENANTHRIDINE MATERIALS UNIVERSAL DISPLAY CORPORATION 2008-12-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080297033-A1 BLUE PHOSPHORESCENT IMIDAZOPHENANTHRIDINE MATERIALS IK, CRY1, MAP1LC3C KDM4E 3612/4885CYP3A4 1210/4885CYP2C19 1878/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.