Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 2/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.35 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8583068 | 0.90 | GHSR (0.43) | GHSRSYKJAK2CTSKPSMB5 | |
| SCHEMBL8585740 | 0.84 | GHSR (0.45) | GHSRCYP3A4SCN9A | |
| SCHEMBL8582291 | 0.81 | SYK (0.42) | GHSRSYKCTSKPSMB5NTSR1 | |
| SCHEMBL8997804 | 0.79 | P2RY1 (0.37) | SYKJAK2CTSKHDAC1HDAC4 | |
| SCHEMBL8581721 | 0.72 | GHSR (0.48) | GHSRMAPTL3MBTL1POLB | |
| SCHEMBL8997594 | 0.71 | SYK (0.40) | SYKJAK2CTSKPSMB5MAPT | |
| SCHEMBL8582293 | 0.70 | SYK (0.44) | GHSRSYKCTSKPSMB5NTSR1 | |
| SCHEMBL8845144 | 0.70 | GHSR (0.39) | GHSRSYKL3MBTL1POLB | |
| SCHEMBL8580708 | 0.69 | GHSR (0.43) | GHSR | |
| SCHEMBL8997810 | 0.69 | P2RY1 (0.39) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5837807-A | DIPEPTIDES AND CYCLIC PEPTIDE DERIVATIVES OF AMINO TETRAHYDRONAPHTHALENECARBOXYLIC ACID AND HELICAL DOMAINS | HOFFMANN-LA ROCHE INC. (US) | 1998-11-17 | — | — | US | disclosed |