Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY1 | P47900 | 9/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | FNTA | P49354 | 2/20 | 0.34 |
| ▸ | FNTB | P49356 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8997594 | 0.93 | SYK (0.40) | SYKJAK2CTSKCYP1A2CYP3A4 | |
| SCHEMBL8997810 | 0.91 | P2RY1 (0.39) | P2RY1KDM4EFNTAFNTBMAPK1 | |
| SCHEMBL8997695 | 0.84 | P2RY1 (0.37) | P2RY1KDM4EFNTAFNTBMAPK1 | |
| SCHEMBL8997628 | 0.84 | CA1 (0.34) | P2RY1SYKKDM4ECYP1A2CYP3A4 | |
| SCHEMBL8997631 | 0.83 | SYK (0.35) | SYKCTSK | |
| SCHEMBL8997778 | 0.81 | MEN1 (0.40) | P2RY1SYKKDM4ECYP3A4ALDH1A1 | |
| SCHEMBL8997612 | 0.81 | SYK (0.41) | SYKCTSKCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8613091 | 0.79 | GHSR (0.40) | SYKJAK2CTSKCYP3A4MAPK1 | |
| SCHEMBL8997648 | 0.78 | SYK (0.38) | SYKHDAC1 | |
| SCHEMBL8997603 | 0.78 | SYK (0.38) | SYKCTSKCYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0729972-A1 | Peptide derivatives of tetrahydronaphthalene | F. HOFFMANN-LA ROCHE AG (CH) | 1996-09-04 | — | — | EP | disclosed |