Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.47 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.47 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8609905 | 0.86 | HTR1F (0.51) | SIGMAR1OPRD1OPRM1ADRA2BADRA2C | |
| SCHEMBL8611280 | 0.83 | OPRM1 (0.49) | SIGMAR1OPRD1OPRM1OPRK1 | |
| SCHEMBL7778382 | 0.82 | HTR1D (0.50) | HTR2A | |
| SCHEMBL8584939 | 0.79 | HTR1D (0.37) | DRD2DRD4DRD3KCNH2HTR2A | |
| SCHEMBL8582998 | 0.79 | DRD2 (0.52) | SIGMAR1DRD2 | |
| SCHEMBL8586783 | 0.76 | CHRM1 (0.48) | SIGMAR1CHRM1DRD2 | |
| SCHEMBL8585332 | 0.75 | SIGMAR1 (0.55) | SIGMAR1DRD2DRD4DRD3KCNH2 | |
| Propionamide SCHEMBL29025290 | 0.75 | SIGMAR1 (0.62) | SIGMAR1OPRD1OPRM1SLC22A1NR1I2 | |
| SCHEMBL8584838 | 0.74 | DRD2 (0.44) | SIGMAR1DRD2DRD4DRD3 | |
| SCHEMBL7008169 | 0.74 | HTR1F (0.74) | HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998020875-A1 | 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 1998-05-22 | — | — | WO | disclosed |