Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 6/20 | 0.49 |
| ▸ | HTR1D | P28221 | 4/20 | 0.46 |
| ▸ | HTR2C | P28335 | 4/20 | 0.44 |
| ▸ | HTR2B | P41595 | 2/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.43 |
| ▸ | MTOR | P42345 | 3/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | HTR1B | P28222 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PRKCA | P17252 | 1/20 | 0.39 |
| ▸ | PRKACB | P22694 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8622676 | 0.81 | HTR2B (0.51) | HTR6HTR2CHTR2BPIK3CAMTOR | |
| SCHEMBL8615837 | 0.76 | POLB (0.39) | HTR1DHTR2AHTR1AHTR1BMAPT | |
| SCHEMBL8587765 | 0.76 | HTR1D (0.44) | HTR1DHTR2CHTR2BHTR2AHTR1A | |
| SCHEMBL8589275 | 0.76 | MEN1 (0.52) | HTR6HTR1DHTR2CHTR2ANPC1 | |
| SCHEMBL8587699 | 0.75 | KDR (0.43) | HTR2CHTR2BKDM4ESMN1; SMN2 | |
| SCHEMBL8588618 | 0.74 | HRH3 (0.41) | HTR1DHTR2CHTR2BHTR1B | |
| SCHEMBL8657486 | 0.72 | KDM4C (0.38) | HTR1DHTR2CHTR2BHTR1AHTR1B | |
| SCHEMBL8590672 | 0.70 | KDR (0.45) | KDM4ESMN1; SMN2 | |
| SCHEMBL8119592 | 0.69 | HTR1A (0.67) | HTR6HTR1DHTR2CHTR2BMTOR | |
| SCHEMBL1122382 | 0.69 | HTR6 (0.51) | HTR6HTR1DHTR2CHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998047868-A1 | HETEROCYCLE-CONTAINING UREA DERIVATIVES AS 5HT1A, 5HT1B AND 5HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1998-10-29 | — | — | WO | claimed |
| WO-1998047868-A1 | HETEROCYCLE-CONTAINING UREA DERIVATIVES AS 5HT1A, 5HT1B AND 5HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1998-10-29 | — | — | WO | disclosed |