Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 6/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 6/20 | 0.37 |
| ▸ | RAB9A | P51151 | 5/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.35 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 3/20 | 0.34 |
| ▸ | KDM6B | O15054 | 2/20 | 0.34 |
| ▸ | KDM4A | O75164 | 1/20 | 0.34 |
| ▸ | KDM4B | O94953 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8587765 | 0.72 | HTR1D (0.44) | HTR1AHTR1DHTR1BNPC1RAB9A | |
| SCHEMBL8587699 | 0.72 | KDR (0.43) | MCHR1KMT2AHTR2CHTR2BKDM4E | |
| SCHEMBL8615090 | 0.72 | HTR6 (0.49) | HTR1AHTR1DHTR1BNPC1RAB9A | |
| SCHEMBL8588618 | 0.71 | HRH3 (0.41) | HTR1DHTR1BMCHR1KMT2AHTR2C | |
| SCHEMBL8130310 | 0.71 | HTR1A (0.44) | HTR1AHTR1DHTR1BMEN1KMT2A | |
| SCHEMBL8615837 | 0.69 | POLB (0.39) | HTR1AHTR1DHTR1BALDH1A1ROCK2 | |
| SCHEMBL6993724 | 0.68 | HTR1D (0.44) | HTR1AHTR1DHTR1BNPC1RAB9A | |
| SCHEMBL6999514 | 0.68 | HTR1D (0.59) | HTR1AHTR1DHTR1B | |
| SCHEMBL8590672 | 0.67 | KDR (0.45) | MCHR1KMT2AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL6812318 | 0.67 | MTNR1A (0.67) | MTNR1ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998047868-A1 | HETEROCYCLE-CONTAINING UREA DERIVATIVES AS 5HT1A, 5HT1B AND 5HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1998-10-29 | — | — | WO | disclosed |