Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PARP14 | Q460N5 | 5/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8617040 | 0.87 | KEAP1 (0.41) | PARP14HTT | |
| SCHEMBL8616305 | 0.87 | MEN1 (0.36) | ALDH1A1SMN1; SMN2HPGDPOLBKDM4E | |
| SCHEMBL8618998 | 0.87 | ABCB1 (0.47) | ALDH1A1SMN1; SMN2L3MBTL1HPGDPOLB | |
| SCHEMBL8613400 | 0.84 | GFER (0.41) | ALDH1A1SMN1; SMN2HPGDPOLBKDM4E | |
| SCHEMBL8618049 | 0.84 | KDM4E (0.41) | ALDH1A1SMN1; SMN2PARP14HPGDPOLB | |
| SCHEMBL8613752 | 0.82 | KMT2A (0.42) | ALDH1A1HPGDPOLBKDM4EMAPT | |
| SCHEMBL8613684 | 0.82 | NPC1 (0.42) | ALDH1A1SMN1; SMN2HPGDPOLBNUDT1 | |
| SCHEMBL8620892 | 0.82 | HTT (0.47) | ALDH1A1SMN1; SMN2HPGDPOLBKDM4E | |
| SCHEMBL8615227 | 0.82 | MAPT (0.33) | ALDH1A1SMN1; SMN2HPGDPOLBKDM4E | |
| SCHEMBL8617403 | 0.82 | KMT2A (0.41) | ALDH1A1L3MBTL1POLBMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0726254-B1 | Quinoline-4-carbonylguanidine derivates, process for producing the same and pharmaceutical preparations containing the compounds | MITSUI TOATSU CHEMICALS (JP) | 1998-05-06 | — | — | EP | disclosed |
| US-5627193-A | MEDICAL DIAGNOSIS, CARDIOVASCULAR DIAORDERS AND PROTECTION OF ORGANS FOR TRANSPLANTATION | MITSUI TOATSU CHEMICALS, INC. (JP) | 1997-05-06 | — | — | US | disclosed |
| EP-0726254-A1 | Quinoline-4-carbonylguanidine derivates, process for producing the same and pharmaceutical preparations containing the compounds | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1996-08-14 | — | — | EP | disclosed |