Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 2/20 | 0.41 |
| ▸ | GLO1 | Q04760 | 3/20 | 0.40 |
| ▸ | PLA2G7 | Q13093 | 3/20 | 0.39 |
| ▸ | PARP14 | Q460N5 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | CKS1B | P61024 | 2/20 | 0.34 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8617546 | 0.87 | ALDH1A1 (0.41) | PARP14HTT | |
| SCHEMBL8619728 | 0.87 | KEAP1 (0.43) | KEAP1GLO1ALOX15HTTMMP2 | |
| SCHEMBL8616305 | 0.86 | MEN1 (0.36) | PLA2G7TP53ALOX15HTT | |
| SCHEMBL8613761 | 0.85 | TP53 (0.40) | KEAP1GLO1PLA2G7TP53NFE2L2 | |
| SCHEMBL8613234 | 0.83 | CDK9 (0.38) | HTT | |
| SCHEMBL8613400 | 0.83 | GFER (0.41) | HTT | |
| SCHEMBL8616047 | 0.83 | ALDH1A1 (0.45) | TP53HTT | |
| SCHEMBL8617771 | 0.83 | ALDH1A1 (0.40) | TP53HTT | |
| SCHEMBL8613368 | 0.82 | CDK9 (0.38) | TP53HTT | |
| SCHEMBL8620892 | 0.81 | HTT (0.47) | HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0726254-B1 | Quinoline-4-carbonylguanidine derivates, process for producing the same and pharmaceutical preparations containing the compounds | MITSUI TOATSU CHEMICALS (JP) | 1998-05-06 | — | — | EP | disclosed |
| US-5627193-A | MEDICAL DIAGNOSIS, CARDIOVASCULAR DIAORDERS AND PROTECTION OF ORGANS FOR TRANSPLANTATION | MITSUI TOATSU CHEMICALS, INC. (JP) | 1997-05-06 | — | — | US | disclosed |
| EP-0726254-A1 | Quinoline-4-carbonylguanidine derivates, process for producing the same and pharmaceutical preparations containing the compounds | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1996-08-14 | — | — | EP | disclosed |