Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
| ▸ | GMNN | O75496 | 1/20 | 0.32 |
| ▸ | TDP2 | O95551 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | NQO1 | P15559 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | POR | P16435 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8621451 | 0.88 | POLB (0.34) | KDM4EMEN1CES2ALDH1A1LMNA | |
| SCHEMBL8620334 | 0.74 | — | — | |
| SCHEMBL2645904 | 0.70 | ALDH1A1 (0.35) | IDO1KDM4EMEN1CES2GMNN | |
| SCHEMBL486948 | 0.69 | KRAS (0.37) | — | |
| SCHEMBL8619722 | 0.67 | GRIN2D (0.33) | — | |
| SCHEMBL11833621 | 0.67 | LMNA (0.37) | IDO1KDM4EMEN1CES2GMNN | |
| SCHEMBL17122007 | 0.64 | ALDH1A1 (0.46) | KDM4EMEN1ALDH1A1MAPTTHRB | |
| SCHEMBL55174 | 0.64 | — | — | |
| SCHEMBL11700035 | 0.64 | TSHR (0.41) | ALDH1A1LMNATP53ALOX15TDP1 | |
| SCHEMBL3030690 | 0.62 | TP53 (0.32) | KDM4EMEN1GMNNLMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230278988-A1 | THRB RECEPTOR AGONIST COMPOUND AND PREPARATION METHOD AND USE THEREOF | TERNS PHARMACEUTICALS, INC. | 2023-09-07 | — | — | US | disclosed |
| US-20230278988-A1 | THRB RECEPTOR AGONIST COMPOUND AND PREPARATION METHOD AND USE THEREOF | TERNS PHARMACEUTICALS, INC. | 2023-09-07 | — | — | US | disclosed |
| US-11084802-B2 | THRβ receptor agonist compound and preparation method and use thereof | Terns, Inc. (US) | 2021-08-10 | — | — | US | disclosed |
| CN-113194958-A | THR beta receptor agonist compound and preparation method and application thereof | 拓臻股份有限公司 | 2021-07-30 | — | — | CN | disclosed |
| US-11034676-B2 | THRB receptor agonist compound and preparation method and use thereof | Terns, Inc. (US) | 2021-06-15 | — | — | US | disclosed |
| US-20200399249-A1 | THRB RECEPTOR AGONIST COMPOUND AND PREPARATION METHOD AND USE THEREOF | TERNS PHARMACEUTICALS, INC. | 2020-12-24 | — | — | US | disclosed |
| CN-111320609-A | THR β receptor agonist compound and preparation method and application thereof | 拓臻股份有限公司 | 2020-06-23 | — | — | CN | disclosed |
| WO-2020123827-A1 | THRΒ RECEPTOR AGONIST COMPOUND AND PREPARATION METHOD AND USE THEREOF | Terns, Inc. (US) | 2020-06-18 | — | — | WO | disclosed |
| US-20200190064-A1 | THRB RECEPTOR AGONIST COMPOUND AND PREPARATION METHOD AND USE THEREOF | TERNS PHARMACEUTICALS, INC. | 2020-06-18 | — | — | US | disclosed |
| EP-0608132-B1 | Coating varnish composition and antifouling coating composition | HITACHI CHEMICAL CO LTD (JP) | 1998-05-20 | — | — | EP | disclosed |
| US-5646198-A | MIXTURE INCLUDES POLYMER, BENZOTRIAZOLE OR TRIAZOLE COMPOUND, AND COMPOUND WITH HYDROPHOBIC AND HYDROPHILIC PARTS; STORAGE STABILITY; MARINE STRUCTURES | HITACHI CHEMICAL COMPANY, LTD. (JP) | 1997-07-08 | — | — | US | disclosed |
| US-5439511-A | Composition containing polymer obtained by polymerizing unsaturated acid anhydride and another unsaturated compound, specified additive | HITACHI CHEMICAL COMPANY, LTD. (JP) | 1995-08-08 | — | — | US | disclosed |
| EP-0659848-A2 | Coating composition and antifouling paint | Hitachi Chemical Co., Ltd. (JP) | 1995-06-28 | — | — | EP | disclosed |
| EP-0608132-A1 | Coating varnish composition and antifouling coating composition | HITACHI CHEMICAL CO., LTD. (JP) | 1994-07-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200190064-A1 | THRB RECEPTOR AGONIST COMPOUND AND PREPARATION METHOD AND USE THEREOF | THRB, THRA, TRHR | IDO1 2110/4885KDM4E 3160/4885MEN1 997/4885 |
| US-20230278988-A1 | THRB RECEPTOR AGONIST COMPOUND AND PREPARATION METHOD AND USE THEREOF | THRB, THRA, TRHR | IDO1 2110/4885KDM4E 3160/4885MEN1 997/4885 |
| US-11034676-B2 | THRB receptor agonist compound and preparation method and use thereof | THRB, THRA, TRHR | IDO1 2110/4885KDM4E 3160/4885MEN1 997/4885 |
| US-11084802-B2 | THRβ receptor agonist compound and preparation method and use thereof | THRB, THRA, TRHR | IDO1 2178/4885KDM4E 3235/4885MEN1 1201/4885 |
| US-20200399249-A1 | THRB RECEPTOR AGONIST COMPOUND AND PREPARATION METHOD AND USE THEREOF | THRB, THRA, TRHR | IDO1 2110/4885KDM4E 3160/4885MEN1 997/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.