Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | EP300 | Q09472 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 2/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.37 |
| ▸ | FLT1 | P17948 | 2/20 | 0.37 |
| ▸ | FLT4 | P35916 | 2/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | MAOA | P21397 | 2/20 | 0.37 |
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8613836 | 0.90 | KDM1A (0.40) | TRIM24KDM1AKDM1BEGFRFGFR1 | |
| SCHEMBL8619975 | 0.85 | KDM1A (0.38) | TRIM24KDM1AKDM1BNPC1MAPT | |
| SCHEMBL8619530 | 0.80 | TRIM24 (0.41) | TRIM24KDM1AKDM1BNPC1MAPT | |
| SCHEMBL8620775 | 0.73 | HTR2C (0.45) | HRH3 | |
| SCHEMBL8617073 | 0.72 | TSHR (0.45) | TRIM24KDM1AKDM1BNPC1MAPT | |
| SCHEMBL18164521 | 0.71 | HTR2A (0.43) | TRIM24MAPT | |
| SCHEMBL8613696 | 0.71 | HRH3 (0.44) | HRH3BRD4EP300CREBBPIRAK4 | |
| SCHEMBL8120191 | 0.65 | TRIM24 (0.50) | HRH3TRIM24KDM1AKDM1BNPC1 | |
| SCHEMBL23063855 | 0.64 | CYP11B1 (0.50) | MAPTSMN1; SMN2 | |
| SCHEMBL25455118 | 0.64 | LMNA (0.58) | TRIM24MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998050346-A2 | ACETAMIDE AND UREA DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF CNS DISORDERS | SMITHKLINE BEECHAM PLC (GB) | 1998-11-12 | — | — | WO | disclosed |