Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 5/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | SHBG | P04278 | 1/20 | 0.31 |
| ▸ | MIF | P14174 | 1/20 | 0.30 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.30 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9250608 | 0.83 | ESR1 (0.37) | ESR1ESR2CYP3A4SHBGMIF | |
| SCHEMBL5140991 | 0.81 | SHBG (0.45) | ESR1ESR2APPCYP3A4CYP2C9 | |
| SCHEMBL9473539 | 0.78 | — | — | |
| SCHEMBL8625814 | 0.75 | SHBG (0.39) | ESR1ESR2APPCYP3A4CYP2C9 | |
| SCHEMBL6157069 | 0.75 | SHBG (0.50) | ESR1ESR2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL18139 | 0.75 | SHBG (0.53) | ESR1ESR2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL11834731 | 0.71 | SHBG (0.33) | SHBG | |
| SCHEMBL3480352 | 0.67 | SHBG (0.52) | ESR1ESR2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL9508102 | 0.66 | ESR1 (0.56) | ESR1ESR2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL15893491 | 0.66 | ESR1 (0.46) | ESR1ESR2CYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5840802-A | HEAT RESISTANCE AND IMPACT STRENGTH FOR THERMOPLASTIC RESINS | GENERAL ELECTRIC COMPANY (US) | 1998-11-24 | — | — | US | disclosed |
| US-5219934-A | POLYMERS CONTAINING SULFONAMIDE UNITS AS COMPATIBILIZERS FOR POLYAMIDE/POLYCARBONATE BLENDS | BAYER AKTIENGESELLSCHAFT (DE) | 1993-06-15 | — | — | US | disclosed |
| EP-0537014-A2 | Dual graft stage and thermally stabilized polyorganisiloxane/polyvinyl-based graft copolymers and thermoplastic compositions containing the same | GENERAL ELECTRIC COMPANY (US) | 1993-04-14 | — | — | EP | disclosed |
| US-5134195-A | Blend of polycarbonate, polyurethane and graft polymer | BAYER AKTIENGESELLSCHAFT (DE) | 1992-07-28 | — | — | US | disclosed |
| US-5106908-A | Thermoplastic resin modifier | GENERAL ELECTRIC COMPANY (US) | 1992-04-21 | — | — | US | disclosed |
| US-5087662-A | Improved impact strength and ductility | GENERAL ELECTRIC COMPANY (US) | 1992-02-11 | — | — | US | disclosed |
| US-4939205-A | IMPACT STRENGTH, WELD LINE STRENGTH, POLYCARBONATES | GENERAL ELECTRIC COMPANY (US) | 1990-07-03 | — | — | US | disclosed |
| EP-0369205-A2 | Thermoplastic molding compositions containing polyorganosiloxane/polyvinyl-based graft polymer modifiers | GENERAL ELECTRIC COMPANY (US) | 1990-05-23 | — | — | EP | disclosed |
| EP-0369202-A2 | Polyester, polycarbonate and/or polyphenylene ether with polyorganosiloxane/polyvinyl-based graft (meth)acrylate polymers | GENERAL ELECTRIC COMPANY (US) | 1990-05-23 | — | — | EP | disclosed |
| EP-0369203-A2 | Polyorganosiloxane/polyvinyl based graft (meth) acrylate polymers | GENERAL ELECTRIC COMPANY (US) | 1990-05-23 | — | — | EP | disclosed |
| US-4375525-A | Use of organic silicon compounds for stabilizing and brightening polycarbonates which are free from phosphites and free from boric acid esters | BAYER AKTIENGESELLSCHAFT (DE) | 1983-03-01 | — | — | US | disclosed |