SCHEMBL8625814

SCHEMBL8625814

CC(C)(CC(C)(CC(Cc1c(-c2ccc(O)cc2)cc(-c2ccc(O)cc2)cc1-c1ccc(O)cc1)c1ccc(O)cc1)c1ccc(O)cc1)c1ccc(O)cc1

nearest known ligand 0.39

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
SHBG P04278 1/20 0.39
ESR1 P03372 4/20 0.33
ESR2 Q92731 4/20 0.33
APP P05067 1/20 0.30
CYP3A4 P08684 1/20 0.30
CYP2C9 P11712 1/20 0.30
CYP2C19 P33261 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9244771 0.78 SHBG (0.51) SHBGESR1ESR2CYP3A4CYP2C9
SCHEMBL5140991 0.78 SHBG (0.45) SHBGESR1ESR2APPCYP3A4
SCHEMBL8625811 0.75 ESR1 (0.34) SHBGESR1ESR2APPCYP3A4
SCHEMBL2143217 0.75 ESR1 (0.47) SHBGESR1ESR2CYP3A4CYP2C9
SCHEMBL18139 0.71 SHBG (0.53) SHBGESR1ESR2CYP3A4CYP2C9
SCHEMBL9220135 0.71 SHBG (0.40) SHBGESR1ESR2CYP3A4CYP2C9
SCHEMBL6157069 0.69 SHBG (0.50) SHBGESR1ESR2CYP3A4CYP2C9
SCHEMBL6060401 0.68 SHBG (0.72) SHBGESR1ESR2CYP3A4
SCHEMBL1201797 0.67 SHBG (0.69) SHBGESR1ESR2CYP3A4
SCHEMBL5174803 0.66 SHBG (0.38) SHBGESR1ESR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10053537-B2 High-fluidity polycarbonate copolymer, process for production highly polymerized aromatic polycarbonate resin and aromatic polycarbonate compound MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2018-08-21 US disclosed
US-9353216-B2 High-fluidity polycarbonate copolymer, process for production highly polymerized aromatic polycarbonate resin and aromatic polycarbonate compound MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2016-05-31 US disclosed
US-20140206826-A1 HIGH-FLUIDITY POLYCARBONATE COPOLYMER, PROCESS FOR PRODUCTION HIGHLY POLYMERIZED AROMATIC POLYCARBONATE RESIN AND AROMATIC POLYCARBONATE COMPOUND (AS AMENDED) MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2014-07-24 US disclosed
US-5840802-A HEAT RESISTANCE AND IMPACT STRENGTH FOR THERMOPLASTIC RESINS GENERAL ELECTRIC COMPANY (US) 1998-11-24 US disclosed
US-5317083-A Process for isolating polycarbonates from their solutions with tube having cross sectional contrictions BAYER AKTIENGESELLSCHAFT (DE) 1994-05-31 US disclosed
US-5219934-A POLYMERS CONTAINING SULFONAMIDE UNITS AS COMPATIBILIZERS FOR POLYAMIDE/POLYCARBONATE BLENDS BAYER AKTIENGESELLSCHAFT (DE) 1993-06-15 US disclosed
EP-0537014-A2 Dual graft stage and thermally stabilized polyorganisiloxane/polyvinyl-based graft copolymers and thermoplastic compositions containing the same GENERAL ELECTRIC COMPANY (US) 1993-04-14 EP disclosed
EP-0535908-A1 Polyester/polycarbonate molding compositions GENERAL ELECTRIC COMPANY (US) 1993-04-07 EP disclosed
US-5134195-A Blend of polycarbonate, polyurethane and graft polymer BAYER AKTIENGESELLSCHAFT (DE) 1992-07-28 US disclosed
US-5106908-A Thermoplastic resin modifier GENERAL ELECTRIC COMPANY (US) 1992-04-21 US disclosed
US-5087662-A Improved impact strength and ductility GENERAL ELECTRIC COMPANY (US) 1992-02-11 US disclosed
US-4939205-A IMPACT STRENGTH, WELD LINE STRENGTH, POLYCARBONATES GENERAL ELECTRIC COMPANY (US) 1990-07-03 US disclosed
EP-0369203-A2 Polyorganosiloxane/polyvinyl based graft (meth) acrylate polymers GENERAL ELECTRIC COMPANY (US) 1990-05-23 EP disclosed
EP-0369205-A2 Thermoplastic molding compositions containing polyorganosiloxane/polyvinyl-based graft polymer modifiers GENERAL ELECTRIC COMPANY (US) 1990-05-23 EP disclosed
EP-0369202-A2 Polyester, polycarbonate and/or polyphenylene ether with polyorganosiloxane/polyvinyl-based graft (meth)acrylate polymers GENERAL ELECTRIC COMPANY (US) 1990-05-23 EP disclosed
US-4548987-A CONTAINING AN UNSATURATED KETONE ESTER BAYER AKTIENGESELLSCHAFT (DE) 1985-10-22 US disclosed
US-4375525-A Use of organic silicon compounds for stabilizing and brightening polycarbonates which are free from phosphites and free from boric acid esters BAYER AKTIENGESELLSCHAFT (DE) 1983-03-01 US disclosed