Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | NOS1 | P29475 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | MAOB | P27338 | 1/20 | 0.58 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.48 |
| ▸ | GSK3B | P49841 | 3/20 | 0.48 |
| ▸ | PIM1 | P11309 | 2/20 | 0.48 |
| ▸ | PRKACA | P17612 | 2/20 | 0.48 |
| ▸ | CDK2 | P24941 | 2/20 | 0.48 |
| ▸ | JAK2 | O60674 | 2/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.48 |
| ▸ | PLK4 | O00444 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | CHUK | O15111 | 1/20 | 0.48 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.48 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.48 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.48 |
| ▸ | PRKCG | P05129 | 1/20 | 0.48 |
| ▸ | CDK1 | P06493 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1730308 | 0.88 | DHFR (0.48) | MAPTLMNARIPK1DHFRSMN1; SMN2 | |
| SCHEMBL31661733 | 0.78 | RAB9A (0.45) | MAPTKDM4CALDH1A1PKMSMN1; SMN2 | |
| SCHEMBL31661574 | 0.77 | POLB (0.47) | MAPTPOLBKDM4CALDH1A1 | |
| SCHEMBL148826 | 0.76 | NOS1 (1.00) | MAPTNOS1POLBMAOBROCK2 | |
| SCHEMBL8556009 | 0.76 | PKM (0.53) | MAPTLMNARIPK1PKMHPGD | |
| SCHEMBL1014119 | 0.76 | KMT2A (0.56) | MAPTPOLBHPGD | |
| Indazole SCHEMBL27786912 | 0.75 | NOS1 (0.85) | MAPTNOS1POLBMAOBROCK2 | |
| Bromide SCHEMBL8520491 | 0.75 | NOS1 (0.97) | MAPTNOS1POLBMAOBROCK2 | |
| Hydrochloric Acid SCHEMBL31587195 | 0.75 | NOS1 (0.97) | MAPTNOS1POLBMAOBROCK2 | |
| Formaldehyde SCHEMBL29009556 | 0.74 | NOS1 (0.93) | MAPTNOS1POLBMAOBROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0843671-A1 | HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLAXO GROUP LIMITED (GB) | 1998-05-27 | — | — | EP | disclosed |