Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.47 |
| ▸ | WNT3A | P56704 | 1/20 | 0.47 |
| ▸ | KCNK3 | O14649 | 4/20 | 0.46 |
| ▸ | KCNK9 | Q9NPC2 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.44 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8628090 | 0.82 | CES2 (0.59) | PARP1SMN1; SMN2KCNK3KCNK9MEN1 | |
| SCHEMBL3198121 | 0.80 | TSHR (0.52) | SMN1; SMN2MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL8627919 | 0.79 | TDP1 (0.53) | HDAC6SMN1; SMN2CTNNB1WNT3AMEN1 | |
| SCHEMBL27426409 | 0.78 | LOXL2 (0.63) | SMN1; SMN2RAB9ANPC1TP53 | |
| SCHEMBL10429075 | 0.78 | CTNNB1 (0.48) | HDAC8HDAC6PARP1SMN1; SMN2CTNNB1 | |
| SCHEMBL29534771 | 0.74 | GPR17 (0.65) | HDAC8HDAC6PARP1SMN1; SMN2CTNNB1 | |
| SCHEMBL40429 | 0.74 | GPR17 (0.65) | HDAC8HDAC6PARP1SMN1; SMN2CTNNB1 | |
| SCHEMBL27582425 | 0.74 | PARP1 (0.59) | HDAC8HDAC6PARP1SMN1; SMN2KCNK3 | |
| SCHEMBL28289702 | 0.74 | GPR17 (0.65) | HDAC8HDAC6PARP1SMN1; SMN2CTNNB1 | |
| SCHEMBL5512015 | 0.73 | TSHR (0.58) | SMN1; SMN2CTNNB1WNT3AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0646570-B1 | PROCESS FOR PRODUCING LIGNAN COMPOUND | SHIONOGI & CO (JP) | 1998-06-24 | — | — | EP | disclosed |
| US-5488134-A | Preparation of compounds of lignan series | SHIONOGI & CO., LTD. (JP) | 1996-01-30 | — | — | US | disclosed |
| EP-0646570-A1 | PROCESS FOR PRODUCING LIGNAN COMPOUND | SHIONOGI & CO., LTD. (JP) | 1995-04-05 | — | — | EP | disclosed |