Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.71 |
| ▸ | CCR9 | P51686 | 1/20 | 0.55 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.55 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.55 |
| ▸ | EGFR | P00533 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 3/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | MDM4 | O15151 | 1/20 | 0.53 |
| ▸ | MITF | O75030 | 1/20 | 0.53 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8622964 | 0.89 | LMNA (0.57) | POLBCCR9GLO1SLC40A1SMN1; SMN2 | |
| SCHEMBL8626109 | 0.85 | CCR9 (0.66) | POLBCCR9GLO1SLC40A1SMN1; SMN2 | |
| SCHEMBL8627655 | 0.82 | KEAP1 (0.67) | POLBSMN1; SMN2LMNAALDH1A1HTT | |
| SCHEMBL8627716 | 0.80 | TUBB4A (0.59) | POLBCCR9GLO1SLC40A1SMN1; SMN2 | |
| SCHEMBL27180977 | 0.79 | F10 (0.64) | EGFRSMN1; SMN2LMNAALDH1A1HTT | |
| SCHEMBL30926697 | 0.79 | F10 (0.64) | EGFRSMN1; SMN2LMNAALDH1A1HTT | |
| SCHEMBL8626468 | 0.79 | SMN1; SMN2 (0.69) | POLBCCR9SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL6561650 | 0.79 | KEAP1 (0.53) | POLBSMN1; SMN2LMNAALDH1A1HTT | |
| SCHEMBL8623537 | 0.79 | KEAP1 (0.56) | POLBCCR9SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL8626192 | 0.79 | KEAP1 (0.56) | POLBCCR9SMN1; SMN2LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0472053-B1 | Sulfonamide derivatives | EISAI CO LTD (JP) | 1998-06-17 | — | — | EP | disclosed |
| US-5610304-A | Pyrimidinyl or pyridinyl sulfonamide substituted compounds | EISAI CO., LTD. (JP) | 1997-03-11 | — | — | US | disclosed |
| US-5610320-A | ANTITUMOR AGENTS | EISAI CO., LTD. (JP) | 1997-03-11 | — | — | US | disclosed |
| US-5434172-A | Antitumor | EISAI CO., LTD. (JP) | 1995-07-18 | — | — | US | disclosed |
| US-5332751-A | Antitumor | EISAI CO., LTD. (JP) | 1994-07-26 | — | — | US | disclosed |
| US-5292758-A | Sulfonamide derivatives | EISAI CO., LTD. (JP) | 1994-03-08 | — | — | US | disclosed |
| US-5250549-A | Antitumor agents | EISAI CO., LTD. (JP) | 1993-10-05 | — | — | US | disclosed |
| EP-0472053-A2 | Sulfonamide derivatives | Eisai Co., Ltd. (JP) | 1992-02-26 | — | — | EP | disclosed |