Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | PPARA | Q07869 | 1/20 | 0.31 |
| ▸ | KIF11 | P52732 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8555710 | 0.73 | LMNA (0.44) | SMN1; SMN2PKMLMNAL3MBTL1POLB | |
| SCHEMBL28557034 | 0.70 | PIN1 (0.47) | SMN1; SMN2PKML3MBTL1POLBALDH1A1 | |
| SCHEMBL11208198 | 0.67 | ALDH1A1 (0.47) | SMN1; SMN2LMNAL3MBTL1POLBMAPK1 | |
| SCHEMBL1357707 | 0.65 | TDP1 (0.45) | LMNAL3MBTL1ALDH1A1MAPTGAA | |
| SCHEMBL11269432 | 0.64 | PKM (0.46) | SMN1; SMN2PKMLMNAL3MBTL1POLB | |
| SCHEMBL15116699 | 0.63 | ALDH1A1 (0.42) | SMN1; SMN2LMNAMAPK1MTNR1AMTNR1B | |
| SCHEMBL11264686 | 0.63 | ALDH1A1 (0.42) | SMN1; SMN2PKMLMNAL3MBTL1POLB | |
| SCHEMBL11871472 | 0.63 | CTSD (0.48) | SMN1; SMN2PKMLMNAL3MBTL1POLB | |
| SCHEMBL6911785 | 0.63 | ALDH1A1 (0.39) | SMN1; SMN2POLBMTNR1AMTNR1BALDH1A1 | |
| Acetic Acid SCHEMBL22497414 | 0.62 | LMNA (0.47) | SMN1; SMN2PKMLMNAL3MBTL1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0880504-A1 | HETEROCYCLO-SUBSTITUTED IMIDAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997027181-A1 | HETEROCYCLO-SUBSTITUTED IMIDAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-07-31 | — | — | WO | disclosed |