Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.36 |
| ▸ | PBK | Q96KB5 | 5/20 | 0.35 |
| ▸ | PDE2A | O00408 | 2/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8633509 | 0.83 | PDE4A (0.39) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL8634009 | 0.81 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL8568221 | 0.80 | ALOX5AP (0.35) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL8574221 | 0.78 | TNKS (0.42) | ADORA3ADORA1PDE2AGSK3BADORA2A | |
| SCHEMBL8629601 | 0.78 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4DADORA3 | |
| SCHEMBL8633900 | 0.78 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DCHRM4 | |
| SCHEMBL8572616 | 0.77 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL2525079 | 0.76 | LMNA (0.36) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL8629585 | 0.76 | GAA (0.38) | PDE4APDE4BPDE4CPDE4DADORA3 | |
| SCHEMBL8627255 | 0.76 | SMN1; SMN2 (0.41) | PDE4APDE4BPDE4CPDE4DADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998005327-A1 | SUBSTITUTED AROMATIC COMPOUNDS | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1998-02-12 | — | — | WO | disclosed |