SCHEMBL8629929

SCHEMBL8629929

CNc1nc(Cl)nc(-c2ccccc2NC(=O)O)n1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 3/20 0.46
LMNA P02545 2/20 0.46
MEN1 O00255 2/20 0.45
KMT2A Q03164 2/20 0.45
MAPT P10636 4/20 0.38
TSHR P16473 3/20 0.38
POLB P06746 2/20 0.38
USP2 O75604 1/20 0.38
HTT P42858 1/20 0.38
ALDH1A1 P00352 3/20 0.37
ACHE P22303 1/20 0.37
KDM4E B2RXH2 3/20 0.37
PKM P14618 2/20 0.37
ABCG2 Q9UNQ0 1/20 0.37
NTRK1 P04629 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
EGFR P00533 1/20 0.36
MAPK1 P28482 2/20 0.36
GAA P10253 1/20 0.36
ALOX15 P16050 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8632527 0.80 ALDH1A1 (0.43) HSD17B10LMNAMEN1KMT2AMAPT
SCHEMBL8627981 0.79 ALDH1A1 (0.50) HSD17B10LMNAMEN1KMT2AMAPT
SCHEMBL8631357 0.77 KMT2A (0.43) HSD17B10LMNAMEN1KMT2AMAPT
SCHEMBL8628902 0.77 MAPT (0.38) HSD17B10LMNAMEN1KMT2AMAPT
SCHEMBL8630090 0.76 NTRK1 (0.46) HSD17B10LMNAMEN1KMT2AMAPT
SCHEMBL8628783 0.75 RAB9A (0.49) HSD17B10LMNAMEN1KMT2AMAPT
SCHEMBL8629851 0.75 KMT2A (0.60) HSD17B10LMNAMEN1KMT2AMAPT
SCHEMBL2262628 0.73 LMNA (0.59) LMNAMEN1KMT2AMAPTHTT
SCHEMBL8627862 0.72 ALDH1A1 (0.46) LMNAMEN1KMT2AMAPTHTT
SCHEMBL8795214 0.71 MAPT (0.41) HSD17B10LMNAMEN1KMT2AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5847126-A N-azinyl-N'-(het) arylsulphonyl-ureas BAYER AKTIENGESELLSCHAFT (DE) 1998-12-08 US disclosed
US-5696257-A INTERMEDIATES FOR HERBICIDES BAYER AKTIENGESELLSCHAFT (DE) 1997-12-09 US disclosed
US-5580842-A HERBICIDES BAYER AKTIENGESELLSCHAFT (DE) 1996-12-03 US disclosed
US-5476936-A Herbicides BAYER AKTIENGESELLSCHAFT (DE) 1995-12-19 US disclosed