Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 9/20 | 0.32 |
| ▸ | SCN1A | P35498 | 2/20 | 0.31 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.31 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | CTSA | P10619 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8634186 | 0.82 | MEN1 (0.41) | P2RX7MEN1KMT2A | |
| SCHEMBL8629431 | 0.79 | BRD4 (0.39) | IDO1TDO2P2RX7 | |
| SCHEMBL9025932 | 0.78 | SLC6A3 (0.42) | IDO1TDO2SCN1ASCN5ASLC6A3 | |
| SCHEMBL28036653 | 0.72 | P2RX7 (0.35) | P2RX7SLC6A3CTSA | |
| SCHEMBL8634034 | 0.72 | MEN1 (0.32) | P2RX7MEN1KMT2A | |
| SCHEMBL8629520 | 0.69 | ACHE (0.44) | IDO1TDO2 | |
| SCHEMBL8633317 | 0.68 | ALOX5 (0.31) | — | |
| SCHEMBL9026067 | 0.67 | SLC6A2 (0.38) | IDO1TDO2P2RX7SLC6A3 | |
| SCHEMBL28763013 | 0.66 | IDO1 (0.41) | IDO1TDO2SLC6A3MEN1KMT2A | |
| SCHEMBL8629570 | 0.66 | GAA (0.44) | IDO1TDO2P2RX7SLC6A3CTSA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5712299-A | TREATMENT OF NEURODEGENERATIVE DISORDERS | ASTRA AKTIEBOLAG (SE) | 1998-01-27 | — | — | US | disclosed |
| EP-0707574-A1 | NOVEL (1-PHENYL-1-HETEROCYCLYL)METHANOL AND (1-PHENYL-1-HETEROCYCLYL)METHYLAMINE DERIVATIVES | Astra Aktiebolag (SE) | 1996-04-24 | — | — | EP | disclosed |
| WO-1995001968-A1 | NOVEL (1-PHENYL-1-HETEROCYCLYL)METHANOL AND (1-PHENYL-1-HETEROCYCLYL)METHYLAMINE DERIVATIVES | ASTRA AKTIEBOLAG (SE) | 1995-01-19 | — | — | WO | disclosed |