Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | TDO2 | P48775 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | ACP3 | P15309 | 1/20 | 0.33 |
| ▸ | CTSA | P10619 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8633796 | 0.84 | ADRB2 (0.36) | P2RX7IDO1TDO2SLC6A3 | |
| SCHEMBL8629431 | 0.84 | BRD4 (0.39) | P2RX7IDO1TDO2 | |
| SCHEMBL8629520 | 0.83 | ACHE (0.44) | IDO1TDO2ALDH1A1LMNAMAPT | |
| SCHEMBL8630486 | 0.81 | KMT2A (0.46) | GAAALDH1A1LMNAMAPTKMT2A | |
| SCHEMBL8683323 | 0.80 | KDM4E (0.43) | P2RX7SLC6A3KDM4EPKMMEN1 | |
| SCHEMBL2593085 | 0.79 | SLC6A3 (0.44) | IDO1TDO2SLC6A3KDM4EPKM | |
| SCHEMBL9525798 | 0.77 | GAA (0.44) | GAAESR1IDO1TDO2ACP3 | |
| SCHEMBL8633347 | 0.73 | TSHR (0.44) | P2RX7IDO1TDO2KDM4EPKM | |
| SCHEMBL598722 | 0.73 | GAA (0.57) | GAAESR1IDO1TDO2SLC6A3 | |
| SCHEMBL8631255 | 0.72 | KMT2A (0.36) | P2RX7KDM4EPKMMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5712299-A | TREATMENT OF NEURODEGENERATIVE DISORDERS | ASTRA AKTIEBOLAG (SE) | 1998-01-27 | — | — | US | disclosed |
| EP-0707574-A1 | NOVEL (1-PHENYL-1-HETEROCYCLYL)METHANOL AND (1-PHENYL-1-HETEROCYCLYL)METHYLAMINE DERIVATIVES | Astra Aktiebolag (SE) | 1996-04-24 | — | — | EP | disclosed |
| WO-1995001968-A1 | NOVEL (1-PHENYL-1-HETEROCYCLYL)METHANOL AND (1-PHENYL-1-HETEROCYCLYL)METHYLAMINE DERIVATIVES | ASTRA AKTIEBOLAG (SE) | 1995-01-19 | — | — | WO | disclosed |