Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | MLKL | Q8NB16 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | TDO2 | P48775 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 3/20 | 0.32 |
| ▸ | SCN1A | P35498 | 2/20 | 0.31 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.31 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12180158 | 0.81 | SLC6A3 (0.39) | SLC6A3SMN1; SMN2KDM4EPKMHTT | |
| SCHEMBL28110012 | 0.81 | SLC6A3 (0.42) | SLC6A3SMN1; SMN2KDM4EPKMHTT | |
| SCHEMBL8630959 | 0.80 | ALDH1A1 (0.41) | SLC6A3SMN1; SMN2KDM4EPKMTSHR | |
| SCHEMBL14962410 | 0.80 | HTT (0.43) | SLC6A3SMN1; SMN2NPSR1KDM4EHTT | |
| SCHEMBL14962409 | 0.79 | SLC6A3 (0.40) | SLC6A3KDM4EPKMHTTMAPT | |
| SCHEMBL8630064 | 0.78 | IDO1 (0.36) | SLC6A3IDO1TDO2SCN1ASCN5A | |
| SCHEMBL8633317 | 0.78 | ALOX5 (0.31) | ALOX5 | |
| SCHEMBL14962433 | 0.78 | HTT (0.41) | SLC6A3SMN1; SMN2KDM4EHTTSCN1A | |
| SCHEMBL9026067 | 0.77 | SLC6A2 (0.38) | SLC6A3IDO1TDO2CYP2D6SLC6A2 | |
| SCHEMBL9026489 | 0.77 | SLC6A3 (0.39) | SLC6A3SMN1; SMN2KDM4EPKMTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8957086-B2 | Compounds and methods of treating brain disorders | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2015-02-17 | — | — | US | disclosed |
| US-8957086-B2 | Compounds and methods of treating brain disorders | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2015-02-17 | — | — | US | disclosed |
| WO-2014013338-A2 | COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | SGC PHARMA, INC. (CA) | 2014-01-23 | — | — | WO | disclosed |
| US-20130131099-A1 | COMPOUNDS AND METHODS OF TREATING BRAIN DISORDERS | THATCHER GREGORY R J (US) | 2013-05-23 | — | — | US | disclosed |
| US-20130131099-A1 | COMPOUNDS AND METHODS OF TREATING BRAIN DISORDERS | THATCHER GREGORY R J (US) | 2013-05-23 | — | — | US | disclosed |
| EP-0707574-A1 | NOVEL (1-PHENYL-1-HETEROCYCLYL)METHANOL AND (1-PHENYL-1-HETEROCYCLYL)METHYLAMINE DERIVATIVES | Astra Aktiebolag (SE) | 1996-04-24 | — | — | EP | disclosed |
| WO-1995001968-A1 | NOVEL (1-PHENYL-1-HETEROCYCLYL)METHANOL AND (1-PHENYL-1-HETEROCYCLYL)METHYLAMINE DERIVATIVES | ASTRA AKTIEBOLAG (SE) | 1995-01-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130131099-A1 | COMPOUNDS AND METHODS OF TREATING BRAIN DISORDERS | NLN, PYGB, OTC | SLC6A3 59/4885SMN1; SMN2 92/4885NPSR1 282/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.