SCHEMBL863028

SCHEMBL863028

O=C(ON1C(=O)CCC1=O)c1cc(OCc2ccccc2)cc(C(=O)ON2C(=O)CCC2=O)c1

nearest known ligand 0.55

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.55
KMT2A Q03164 1/20 0.55
NR4A2 P43354 2/20 0.49
NAAA Q02083 3/20 0.48
MAOB P27338 2/20 0.47
HPD P32754 1/20 0.46
NR4A1 P22736 1/20 0.46
NR4A3 Q92570 1/20 0.46
SMPD1 P17405 1/20 0.45
ALDH1A1 P00352 1/20 0.44
SRD5A2 P31213 2/20 0.44
GCK P35557 1/20 0.44
PARP10 Q53GL7 1/20 0.43
PTPN1 P18031 1/20 0.43
LMNA P02545 1/20 0.43
HPGD P15428 1/20 0.43
HRH3 Q9Y5N1 1/20 0.42
FAAH O00519 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL862827 0.88 NR4A1 (0.57) MEN1KMT2ANR4A2NAAAMAOB
SCHEMBL21805840 0.81 TSHR (0.40) KMT2ANAAAALDH1A1SRD5A2LMNA
SCHEMBL5551769 0.78 LMNA (0.42) MEN1KMT2ANR4A2NAAAMAOB
SCHEMBL13404895 0.78 MGLL (0.37) MEN1KMT2AALDH1A1LMNAHPGD
SCHEMBL6851170 0.77 KMT2A (0.68) MEN1KMT2ANR4A2MAOBNR4A1
SCHEMBL21110476 0.77 KMT2A (0.42) MEN1KMT2AALDH1A1HPGD
SCHEMBL19309377 0.76 KMT2A (0.53) KMT2AALDH1A1LMNA
SCHEMBL133554 0.76 KMT2A (0.53) KMT2AALDH1A1LMNA
SCHEMBL10041303 0.76 LMNA (0.47) MEN1KMT2AALDH1A1SRD5A2LMNA
SCHEMBL183994 0.76 LMNA (0.70) MEN1KMT2ANR4A2MAOBNR4A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8143366-B2 Aryl carbamate oligomers for hydrolyzable prodrugs and prodrugs comprising same BIOCON LIMITED (IN) 2012-03-27 US disclosed
US-8143366-B2 Aryl carbamate oligomers for hydrolyzable prodrugs and prodrugs comprising same BIOCON LIMITED (IN) 2012-03-27 US disclosed
US-20100081782-A1 ARYL CARBAMATE OLIGOMERS FOR HYDROLYZABLE PRODRUGS AND PRODRUGS COMPRISING SAME EKWURIBE NNOCHIRI N 2010-04-01 US disclosed
US-20100081782-A1 ARYL CARBAMATE OLIGOMERS FOR HYDROLYZABLE PRODRUGS AND PRODRUGS COMPRISING SAME EKWURIBE NNOCHIRI N 2010-04-01 US disclosed
US-7625995-B2 Aryl carbamate oligomers for hydrolyzable prodrugs and prodrugs comprising same BIOCON LIMITED (IN) 2009-12-01 US disclosed
US-7625995-B2 Aryl carbamate oligomers for hydrolyzable prodrugs and prodrugs comprising same BIOCON LIMITED (IN) 2009-12-01 US disclosed
US-20080146778-A1 ARYL CARBAMATE OLIGOMERS FOR HYDROLYZABLE PRODRUGS AND PRODRUGS COMPRISING SAME BIOCON LIMITED (IN) 2008-06-19 US disclosed
US-20080146778-A1 ARYL CARBAMATE OLIGOMERS FOR HYDROLYZABLE PRODRUGS AND PRODRUGS COMPRISING SAME BIOCON LIMITED (IN) 2008-06-19 US disclosed
US-7335751-B2 Aryl carbamate oligomers for hydrolyzable prodrugs and prodrugs comprising same BIOCON LIMITED (IN) 2008-02-26 US disclosed
US-7335751-B2 Aryl carbamate oligomers for hydrolyzable prodrugs and prodrugs comprising same BIOCON LIMITED (IN) 2008-02-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080146778-A1 ARYL CARBAMATE OLIGOMERS FOR HYDROLYZABLE PRODRUGS AND PRODRUGS COMPRISING SAME ALK, AOX1, OGFR MEN1 4097/4885KMT2A 1543/4885NR4A2 1535/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.