SCHEMBL8630686

SCHEMBL8630686

CCC(C)S(=O)(=O)NC1CN(c2ccncc2)CCN1C(CCC(=O)O)Oc1ccccc1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ITGB3 P05106 5/20 0.37
ITGA2B P08514 5/20 0.37
TSHR P16473 2/20 0.34
ROCK2 O75116 2/20 0.34
HSD17B10 Q99714 1/20 0.34
F10 P00742 3/20 0.32
SMN1; SMN2 Q16637 3/20 0.32
CYP2C9 P11712 2/20 0.32
ALDH1A1 P00352 2/20 0.32
CYP2D6 P10635 1/20 0.32
MAPK1 P28482 1/20 0.32
HIF1A Q16665 1/20 0.32
FFAR4 Q5NUL3 2/20 0.32
HRH3 Q9Y5N1 1/20 0.32
CYP3A4 P08684 1/20 0.32
CYP2C19 P33261 1/20 0.32
ACACB O00763 1/20 0.32
CYP1A2 P05177 1/20 0.31
LIMK2 P53671 1/20 0.31
PRKG1 Q13976 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8686282 0.94 ROCK2 (0.35) ITGB3ITGA2BTSHRROCK2HSD17B10
SCHEMBL7450096 0.80 ITGB3 (0.42) ITGB3ITGA2BTSHRROCK2HSD17B10
SCHEMBL7398021 0.79 ITGB3 (0.39) ITGB3ITGA2BTSHRROCK2HSD17B10
SCHEMBL7403452 0.75 ITGB3 (0.37) ITGB3ITGA2BTSHRF10SMN1; SMN2
SCHEMBL8697195 0.73 ROCK2 (0.38) ITGB3ITGA2BTSHRROCK2HSD17B10
SCHEMBL8633129 0.73 KDM4D (0.35) ITGB3ITGA2BTSHRROCK2F10
SCHEMBL8698839 0.73 FAAH (0.37) ITGB3ITGA2BTSHRHSD17B10F10
SCHEMBL8635810 0.71 NPSR1 (0.34) ITGB3ITGA2BTSHRHSD17B10F10
SCHEMBL8633503 0.70 MAPT (0.34) ITGB3ITGA2BTSHRSMN1; SMN2CYP2C9
SCHEMBL7400228 0.70 ITGB3 (0.40) ITGB3ITGA2BTSHRHSD17B10SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5753659-A ANTICOAGULANTS FOR BLOOD DISORDER, CARDIOVASCULAR DISORDER, THROMBOSIS, ZENECA LIMITED (GB) 1998-05-19 US disclosed
US-5750754-A TERTIARY BUTYL 3-METHYL-4-SUBSTITUTED BUTYRATE; CHEMICAL INTERMEDIATES FOR ANTICAOGULANT DRUGS ZENECA LIMITED (GB) 1998-05-12 US disclosed