Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SIRT6 | Q8N6T7 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.40 |
| ▸ | BCL9 | O00512 | 1/20 | 0.40 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8631350 | 0.90 | MAPT (0.46) | MAPTKMT2APOLBMEN1CYP2C19 | |
| SCHEMBL8635347 | 0.83 | ITGB3 (0.44) | MAPTALDH1A1GAAITGB3ITGA2B | |
| SCHEMBL8630666 | 0.81 | ITGB3 (0.42) | ALDH1A1GAAITGB3ITGA2B | |
| SCHEMBL8650198 | 0.81 | MAPT (0.44) | MAPTKMT2APOLBMEN1CYP2C19 | |
| SCHEMBL8887870 | 0.81 | MAPT (0.47) | MAPTKMT2APOLBMEN1CYP2C19 | |
| SCHEMBL7402481 | 0.79 | ENPP2 (0.49) | MAPTKMT2APOLBMEN1CYP2C19 | |
| SCHEMBL28776408 | 0.75 | BCL9 (0.50) | MAPTKMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL8635350 | 0.75 | HTR1A (0.41) | MAPTALDH1A1GAAITGB3ITGA2B | |
| SCHEMBL22321541 | 0.74 | MAPT (0.47) | MAPTPOLBLMNAALDH1A1GAA | |
| SCHEMBL27768435 | 0.74 | BCL9 (0.62) | MAPTKMT2AMEN1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5753659-A | ANTICOAGULANTS FOR BLOOD DISORDER, CARDIOVASCULAR DISORDER, THROMBOSIS, | ZENECA LIMITED (GB) | 1998-05-19 | — | — | US | disclosed |
| US-5728701-A | INHIBIT PLATELET AGGREGATION | ZENECA LIMITED (GB) | 1998-03-17 | — | — | US | disclosed |