Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.41 |
| ▸ | SIRT6 | Q8N6T7 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8631347 | 0.90 | MAPT (0.47) | MAPTKMT2AMEN1POLBCYP2C19 | |
| SCHEMBL8635350 | 0.84 | HTR1A (0.41) | MAPTGAAALDH1A1 | |
| SCHEMBL8887870 | 0.79 | MAPT (0.47) | MAPTKMT2AMEN1POLBCYP2C19 | |
| SCHEMBL8650198 | 0.78 | MAPT (0.44) | MAPTKMT2AMEN1POLBCYP2C19 | |
| SCHEMBL7402481 | 0.77 | ENPP2 (0.49) | MAPTKMT2AMEN1POLBCYP2C19 | |
| SCHEMBL8635347 | 0.75 | ITGB3 (0.44) | MAPTGAAALDH1A1 | |
| SCHEMBL27596079 | 0.74 | BCL9 (0.42) | MAPTKMT2AMEN1POLBALDH1A1 | |
| SCHEMBL8630666 | 0.73 | ITGB3 (0.42) | GAAALDH1A1 | |
| SCHEMBL28913685 | 0.70 | L3MBTL1 (0.40) | MAPTKMT2AMEN1CYP2C19ALDH1A1 | |
| SCHEMBL8635008 | 0.70 | ITGB3 (0.44) | GAAALDH1A1HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5753659-A | ANTICOAGULANTS FOR BLOOD DISORDER, CARDIOVASCULAR DISORDER, THROMBOSIS, | ZENECA LIMITED (GB) | 1998-05-19 | — | — | US | disclosed |
| US-5728701-A | INHIBIT PLATELET AGGREGATION | ZENECA LIMITED (GB) | 1998-03-17 | — | — | US | disclosed |