Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | TDO2 | P48775 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | ACP3 | P15309 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8629576 | 0.84 | BRD4 (0.44) | GLAALDH1A1MAPTMAPK1SMN1; SMN2 | |
| SCHEMBL8634802 | 0.84 | ALDH1A1 (0.38) | GLAALDH1A1MAPTMAPK1SMN1; SMN2 | |
| SCHEMBL8632971 | 0.81 | NOTUM (0.38) | GAAGLAMAPTSMN1; SMN2ACP3 | |
| SCHEMBL8634779 | 0.75 | KMT2A (0.38) | GLAALDH1A1MAPTMAPK1SMN1; SMN2 | |
| SCHEMBL598722 | 0.73 | GAA (0.57) | GAAESR1ALDH1A1MAPTIDO1 | |
| SCHEMBL8633722 | 0.72 | BRD4 (0.41) | ALDH1A1MAPTMAPK1SMN1; SMN2LMNA | |
| SCHEMBL8630595 | 0.72 | CES2 (0.38) | GAABRD4 | |
| SCHEMBL8634032 | 0.71 | IMPDH2 (0.39) | ALDH1A1MAPTMAPK1SMN1; SMN2IDO1 | |
| SCHEMBL8981642 | 0.70 | ALDH1A1 (0.39) | ALDH1A1MAPTMAPK1SMN1; SMN2IDO1 | |
| SCHEMBL8636185 | 0.70 | BRD4 (0.43) | ALDH1A1MAPTMAPK1SMN1; SMN2BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5712299-A | TREATMENT OF NEURODEGENERATIVE DISORDERS | ASTRA AKTIEBOLAG (SE) | 1998-01-27 | — | — | US | disclosed |
| EP-0707574-A1 | NOVEL (1-PHENYL-1-HETEROCYCLYL)METHANOL AND (1-PHENYL-1-HETEROCYCLYL)METHYLAMINE DERIVATIVES | Astra Aktiebolag (SE) | 1996-04-24 | — | — | EP | disclosed |
| WO-1995001968-A1 | NOVEL (1-PHENYL-1-HETEROCYCLYL)METHANOL AND (1-PHENYL-1-HETEROCYCLYL)METHYLAMINE DERIVATIVES | ASTRA AKTIEBOLAG (SE) | 1995-01-19 | — | — | WO | disclosed |