Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 8/20 | 0.41 |
| ▸ | MLKL | Q8NB16 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8636185 | 0.86 | BRD4 (0.43) | BRD4CYP3A4CYP2C19KMT2ANOTUM | |
| SCHEMBL8634032 | 0.80 | IMPDH2 (0.39) | BRD4LMNATSHRHSD17B10ACHE | |
| SCHEMBL9026125 | 0.76 | BRD4 (0.36) | BRD4KMT2ACREBBP | |
| SCHEMBL9026465 | 0.75 | ALDH1A1 (0.39) | BRD4LMNATSHRHSD17B10CREBBP | |
| SCHEMBL8634779 | 0.74 | KMT2A (0.38) | CYP2C19KMT2ALMNAHSD17B10ALDH1A1 | |
| SCHEMBL8632301 | 0.72 | GAA (0.44) | BRD4LMNATSHRHSD17B10ALDH1A1 | |
| SCHEMBL96180 | 0.71 | ACHE (0.50) | BRD4MLKLCYP3A4CYP2D6CYP2C19 | |
| SCHEMBL8629576 | 0.70 | BRD4 (0.44) | BRD4CYP3A4NOTUMACHEALDH1A1 | |
| SCHEMBL8634802 | 0.70 | ALDH1A1 (0.38) | CYP2D6CYP2C19NOTUMLMNATSHR | |
| Hydrochloric Acid SCHEMBL29699724 | 0.69 | ACHE (0.47) | BRD4MLKLCYP3A4CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5712299-A | TREATMENT OF NEURODEGENERATIVE DISORDERS | ASTRA AKTIEBOLAG (SE) | 1998-01-27 | — | — | US | disclosed |
| EP-0707574-A1 | NOVEL (1-PHENYL-1-HETEROCYCLYL)METHANOL AND (1-PHENYL-1-HETEROCYCLYL)METHYLAMINE DERIVATIVES | Astra Aktiebolag (SE) | 1996-04-24 | — | — | EP | disclosed |
| WO-1995001968-A1 | NOVEL (1-PHENYL-1-HETEROCYCLYL)METHANOL AND (1-PHENYL-1-HETEROCYCLYL)METHYLAMINE DERIVATIVES | ASTRA AKTIEBOLAG (SE) | 1995-01-19 | — | — | WO | disclosed |