Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | PTGES2 | Q9H7Z7 | 3/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.39 |
| ▸ | FEN1 | P39748 | 3/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.37 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8631499 | 0.86 | FABP1 (0.41) | PTGES2ALOX5APFEN1CA12CA1 | |
| SCHEMBL7780022 | 0.83 | MAP2K7 (0.50) | CA4PTGS1PTGS2CA12CA1 | |
| SCHEMBL8629321 | 0.81 | PTGS2 (0.59) | ALOX5APFEN1PTGS1PTGS2CDK2 | |
| SCHEMBL8631181 | 0.79 | PTGS2 (0.50) | ALOX5APFEN1PTGS1PTGS2CA9 | |
| SCHEMBL8629397 | 0.79 | ALOX5AP (0.40) | CA4PTGES2ALOX5APFEN1CA12 | |
| SCHEMBL8630534 | 0.79 | MAPT (0.60) | PTGES2PTGS2MEN1LMNATSHR | |
| SCHEMBL8629486 | 0.79 | ALOX5AP (0.44) | PTGES2ALOX5APFEN1LMNAMAPK1 | |
| SCHEMBL8631047 | 0.78 | ALOX5AP (0.42) | PTGES2ALOX5APFEN1PTGS1PTGS2 | |
| SCHEMBL8627772 | 0.77 | PTGS2 (0.47) | CA4PTGES2PTGS1PTGS2BRD4 | |
| SCHEMBL7777902 | 0.77 | PTGS2 (0.46) | PTGS1PTGS2CCNT1CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |