Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | EDNRB | P24530 | 1/20 | 0.43 |
| ▸ | EDNRA | P25101 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | OXTR | P30559 | 1/20 | 0.40 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8631516 | 0.93 | PTGS2 (0.46) | MAPTPOLBMEN1KMT2AHTT | |
| SCHEMBL8628005 | 0.93 | MAPT (0.47) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL8632451 | 0.92 | KDM1A (0.45) | EDNRBEDNRAPOLBOXTRAVPR1A | |
| SCHEMBL8632194 | 0.90 | KMT2A (0.40) | MAPTEDNRBEDNRAPOLBMEN1 | |
| SCHEMBL8629307 | 0.90 | GAA (0.47) | MAPTPOLBMEN1KMT2AKEAP1 | |
| SCHEMBL8631851 | 0.85 | MAPT (0.39) | MAPTMEN1KMT2AKEAP1NFE2L2 | |
| SCHEMBL8632849 | 0.85 | MAPT (0.39) | MAPTOXTRAVPR1AMEN1KMT2A | |
| SCHEMBL8632875 | 0.84 | SMN1; SMN2 (0.50) | MAPTEDNRBEDNRAMEN1KMT2A | |
| SCHEMBL8634385 | 0.83 | ACLY (0.42) | MAPTPOLBMEN1KMT2AALDH1A1 | |
| SCHEMBL8629545 | 0.83 | NPC1 (0.41) | ALDH1A1HTTSMN1; SMN2KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |