Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | WRN | Q14191 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | DGKA | P23743 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25923066 | 0.82 | NAAA (0.44) | NAAAGAAHTTHPGDALDH1A1 | |
| SCHEMBL16272977 | 0.82 | HTR1A (0.31) | HTR1ADRD2HTR2AHTR7HPGD | |
| SCHEMBL19523497 | 0.78 | ALDH1A1 (0.43) | HTR1ADRD2HTR2AHTR7GAA | |
| SCHEMBL15583422 | 0.78 | NAAA (0.52) | NAAAGAAHTTHPGDALDH1A1 | |
| SCHEMBL844708 | 0.77 | POLB (0.40) | HTR1ADRD2HTR2AHTR7GAA | |
| SCHEMBL4698870 | 0.77 | LMNA (0.43) | HTR1ADRD2HTR2AHTR7HPGD | |
| SCHEMBL15184972 | 0.76 | — | — | |
| SCHEMBL8520233 | 0.75 | TDP1 (0.52) | NAAAGAAHTTHPGDALDH1A1 | |
| SCHEMBL14389723 | 0.74 | NAAA (0.48) | NAAAGAAHTTHPGDALDH1A1 | |
| SCHEMBL50301 | 0.74 | NAAA (0.64) | NAAAGAAHTTHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8299266-B2 | Processes for making epothilone compounds and analogs | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-10-30 | — | — | US | disclosed |
| US-20120178941-A1 | PROCESSES FOR MAKING EPOTHILONE COMPOUNDS AND ANALOGS | BRISTOL-MYERS SQUIBB COMPANY | 2012-07-12 | — | — | US | disclosed |
| US-8143415-B2 | Processes for making epothilone compounds and analogs | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |
| US-20100324302-A1 | PROCESSES FOR MAKING EPOTHILONE COMPOUNDS AND ANALOGS | BRISTOL-MYERS SQUIBB COMPANY | 2010-12-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100324302-A1 | PROCESSES FOR MAKING EPOTHILONE COMPOUNDS AND ANALOGS | DHPS, EPOR, SQLE | NAAA 3023/4885HTR1A 4439/4885DRD2 3703/4885 |
| US-20120178941-A1 | PROCESSES FOR MAKING EPOTHILONE COMPOUNDS AND ANALOGS | EPOR, PYCR1, AZI2 | NAAA 4598/4885HTR1A 4393/4885DRD2 2102/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.