SCHEMBL8633645

SCHEMBL8633645

COc1cc(OC)cc(Oc2ccc(OCC=C(Cl)Cl)c(C(F)(F)F)c2)c1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AR P10275 9/20 0.38
NQO2 P16083 1/20 0.36
PTGS1 P23219 1/20 0.36
HTT P42858 1/20 0.35
PTGDR2 Q9Y5Y4 1/20 0.35
PDE4A P27815 1/20 0.34
PDE4B Q07343 1/20 0.34
PDE4C Q08493 1/20 0.34
PDE4D Q08499 1/20 0.34
MAPT P10636 2/20 0.34
NPSR1 Q6W5P4 2/20 0.34
L3MBTL1 Q9Y468 2/20 0.34
EPHX2 P34913 1/20 0.34
LMNA P02545 1/20 0.34
GAA P10253 1/20 0.34
ATM Q13315 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
AKR1B10 O60218 1/20 0.34
AKR1C4 P17516 1/20 0.34
AKR1C3 P42330 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8633073 0.94 L3MBTL1 (0.39) ARHTTPTGDR2MAPTNPSR1
SCHEMBL8633011 0.93 MAPT (0.43) ARMAPTNPSR1L3MBTL1EPHX2
SCHEMBL8636160 0.90 AR (0.42) ARHTTMAPT
SCHEMBL8634961 0.86 RXRA (0.35) ARHTTMAPTL3MBTL1LMNA
SCHEMBL8635779 0.86 AR (0.39) ARHTTMAPTGAASMN1; SMN2
SCHEMBL8638861 0.85 AR (0.38) ARMAPTGAASMN1; SMN2
SCHEMBL8635048 0.85 MAPT (0.44) ARHTTMAPTL3MBTL1LMNA
SCHEMBL8636474 0.85 RXRA (0.38) ARPDE4APDE4BPDE4CPDE4D
SCHEMBL8634174 0.85 AR (0.39) ARPTGDR2
SCHEMBL8636591 0.85 MAPK1 (0.43) ARMAPTL3MBTL1LMNAATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0648729-B1 Dihalopropene compound, insecticide/acaricide containing said dihalopropene compound as active ingredient and intermediate compound for use in production of said dihalopropene compound SUMITOMO CHEMICAL CO (JP) 1998-07-15 EP disclosed
US-5698702-A INTERMEDIATES FOR INSECTICIDES, ACARICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1997-12-16 US disclosed
US-5530015-A Dihaloprene compound, insecticide/acaricide containing said dihalopropene compound as active ingredient, and intermediate compound for use in production of said dihalopropene compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1996-06-25 US disclosed
EP-0648729-A1 Dihalopropene compound, insecticide/acaricide containing said dihalopropene compound as active ingredient and intermediate compound for use in production of said dihalopropene compound SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1995-04-19 EP disclosed