Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 2/20 | 0.44 |
| ▸ | DRD2 | P14416 | 4/20 | 0.43 |
| ▸ | DRD3 | P35462 | 4/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8631478 | 0.84 | ALDH1A1 (0.54) | SLC6A4DRD2DRD3HTR1AADRA2A | |
| SCHEMBL8633681 | 0.80 | RECQL (0.50) | DRD2DRD3HTR1AADRA1AADRA1D | |
| SCHEMBL8629425 | 0.78 | DRD4 (0.56) | DRD2DRD3HTR1AADRA1AADRA1D | |
| SCHEMBL8631570 | 0.78 | MAPT (0.47) | SLC6A4DRD2DRD3HTR1AKDM4E | |
| SCHEMBL8629124 | 0.78 | DRD4 (0.48) | SLC6A4DRD2DRD3HTR1AADRA1A | |
| SCHEMBL8631540 | 0.78 | KCNH2 (0.51) | DRD2DRD3HTR1AALDH1A1POLB | |
| SCHEMBL8630582 | 0.75 | MAPT (0.54) | DRD2HTR1AALDH1A1POLBMAPT | |
| SCHEMBL8630535 | 0.75 | SIGMAR1 (0.53) | SLC6A4DRD2DRD3HTR1AADRA2A | |
| SCHEMBL8628212 | 0.74 | SMO (0.42) | SLC6A4DRD2DRD3HTR1AADRA2A | |
| SCHEMBL8633899 | 0.74 | KMT2A (0.50) | ADRA1AADRA1DADRA1BALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5780475-A | Antipsychotic indazole derivatives | MERCK, SHARP & DOHME LIMITED (GB) | 1998-07-14 | — | — | US | disclosed |