Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | SI | P14410 | 2/20 | 0.56 |
| ▸ | MGAM2 | Q2M2H8 | 2/20 | 0.56 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.48 |
| ▸ | PTGES | O14684 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.45 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12473329 | 0.80 | MGAM (0.57) | MGAMGAASIMGAM2NR4A2 | |
| SCHEMBL864263 | 0.75 | HPGD (0.54) | GAAALOX5PTGS1PTGS2PTGES | |
| SCHEMBL3832934 | 0.74 | GAA (0.71) | MGAMGAASIMGAM2PTGS1 | |
| Bicarbonate SCHEMBL9638235 | 0.70 | FFAR1 (0.71) | PTGS1PTGS2NR4A2MAOBNR4A1 | |
| SCHEMBL23120532 | 0.69 | LTA4H (0.64) | ALOX5PTGS1PTGS2NR4A2PTGES | |
| SCHEMBL23120176 | 0.69 | ALOX5 (0.56) | ALOX5PTGS1PTGS2NR4A2PTGES | |
| SCHEMBL10465707 | 0.68 | ALOX5 (0.58) | ALOX5PTGS1PTGS2NR4A2L3MBTL1 | |
| SCHEMBL197017 | 0.67 | LMNA (0.72) | MGAMGAASIMGAM2ALOX5 | |
| SCHEMBL825414 | 0.67 | LMNA (0.63) | ALOX5MEN1NPC1RAB9AKMT2A | |
| SCHEMBL9707249 | 0.67 | ALOX5 (1.00) | ALOX5PTGS1PTGS2NR4A2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8476302-B2 | α-ketoamide derivatives useful endothelial lipase inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 2013-07-02 | — | — | US | disclosed |
| US-20120077847-A1 | ALPHA-KETOAMIDE DERIVATIVES USEFUL ENDOTHELIAL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2012-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120077847-A1 | ALPHA-KETOAMIDE DERIVATIVES USEFUL ENDOTHELIAL LIPASE INHIBITORS | LIPG, LIPA, LIPE | MGAM 50/4885GAA 29/4885SI 130/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.