SCHEMBL8634112

SCHEMBL8634112

COc1cc2c(c(C(C)(C)C)c1)OP(c1ccccc1)Oc1c(cc(OC)cc1C(C)(C)C)C2

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 1/20 0.37
CA2 P00918 1/20 0.37
DRD2 P14416 7/20 0.33
DRD1 P21728 7/20 0.33
DRD5 P21918 7/20 0.33
DRD3 P35462 7/20 0.33
DRD4 P21917 5/20 0.33
CYP3A4 P08684 2/20 0.33
KDM4E B2RXH2 1/20 0.33
MEN1 O00255 1/20 0.33
USP2 O75604 1/20 0.33
ALDH1A1 P00352 1/20 0.33
TP53 P04637 1/20 0.33
MAPT P10636 1/20 0.33
HPGD P15428 1/20 0.33
KMT2A Q03164 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
TRPV1 Q8NER1 1/20 0.33
HSD17B10 Q99714 1/20 0.33
LPAR1 Q92633 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8636490 0.82 CYP1A2 (0.33) CYP3A4CYP2C9CYP2C19
SCHEMBL8634557 0.82 ALDH1A1 (0.33) CA2ALDH1A1SMN1; SMN2
SCHEMBL8908187 0.81 ALDH1A1 (0.32) CA2ALDH1A1SMN1; SMN2
SCHEMBL13681574 0.77 CA2 (0.32) CA2ALDH1A1
SCHEMBL8908019 0.73 CA1 (0.44) CA1CA2DRD2DRD1DRD5
SCHEMBL8634746 0.72 CNR2 (0.35)
SCHEMBL8632989 0.72 ALDH1A1 (0.33) CA2ALDH1A1SMN1; SMN2
SCHEMBL12908800 0.72 ALDH1A1 (0.33) CYP3A4MEN1ALDH1A1KMT2A
SCHEMBL10039476 0.71 KIF11 (0.31)
SCHEMBL8631123 0.70

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5712403-A CATALYST MITSUBISHI CHEMICAL CORPORATION (JP) 1998-01-27 US disclosed