Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 3/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | BRD1 | O95696 | 1/20 | 0.40 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.40 |
| ▸ | BRPF3 | Q9ULD4 | 1/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.39 |
| ▸ | NSD2 | O96028 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8629545 | 0.90 | NPC1 (0.41) | ACLYPTGS1PTGS2ALDH1A1KDM4E | |
| SCHEMBL8629955 | 0.88 | MAPT (0.46) | ACLYPTGS1PTGS2ALDH1A1KDM4E | |
| SCHEMBL8630041 | 0.86 | CCR4 (0.40) | ACLYPTGS1PTGS2ALDH1A1KDM4E | |
| SCHEMBL8634282 | 0.86 | EDNRA (0.38) | ACLYPTGS1PTGS2ALDH1A1KDM4E | |
| SCHEMBL8628055 | 0.86 | MAPT (0.40) | ACLYPTGS1PTGS2ALDH1A1KDM4E | |
| SCHEMBL8631851 | 0.85 | MAPT (0.39) | PTGS2ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL8629307 | 0.85 | GAA (0.47) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| SCHEMBL8627950 | 0.85 | MAPT (0.38) | ACLYPTGS1PTGS2ALDH1A1KDM4E | |
| SCHEMBL8628005 | 0.83 | MAPT (0.47) | PTGS1PTGS2ALDH1A1KDM4EMAPT | |
| SCHEMBL8629978 | 0.83 | MAPT (0.43) | PTGS2ALDH1A1KDM4EMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |