Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | RXRB | P28702 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.31 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.31 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.31 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.31 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.31 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8634504 | 0.89 | FLT1 (0.38) | KMT2ARXRALMNAKDM4EMAPT | |
| SCHEMBL8635203 | 0.88 | HSP90AA1 (0.35) | MCL1KMT2AL3MBTL1LMNATP53 | |
| SCHEMBL8635349 | 0.87 | ALDH1A1 (0.39) | KMT2ALMNAKDM4EMAPTHTT | |
| SCHEMBL8632126 | 0.86 | TUBB4A (0.37) | KMT2ALMNAKDM4EALDH1A1 | |
| SCHEMBL8635757 | 0.86 | SMN1; SMN2 (0.31) | LMNAMAPTMAPK1ALDH1A1 | |
| SCHEMBL8635192 | 0.85 | RXRA (0.35) | KMT2AL3MBTL1RXRARXRBLMNA | |
| SCHEMBL8634221 | 0.85 | SIRT2 (0.34) | LMNAALDH1A1PSEN1PSEN2APH1B | |
| SCHEMBL8635259 | 0.83 | ALDH1A1 (0.38) | KMT2AALOX15ALDH1A1RIPK1 | |
| SCHEMBL7765534 | 0.83 | SLC9A1 (0.45) | — | |
| SCHEMBL8633117 | 0.81 | PDE4B (0.40) | KMT2ARXRARXRBLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1057999-C | 4-Aminobenzoylguanidine derivatives | MERCK PATENT GMBH (DE) | 2000-11-01 | — | — | CN | disclosed |
| US-5739142-A | 4-aminobenzoylguanidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-04-14 | — | — | US | disclosed |
| CN-1138575-A | 4-aminobenzoylguanidine derivatives | MERCK PATENT GMBH (DE) | 1996-12-25 | — | — | CN | disclosed |