Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 2/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | ALPL | P05186 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8635462 | 0.86 | PDE4B (0.41) | NPC1PDE4BALDH1A1TP53NAMPT | |
| SCHEMBL8635344 | 0.85 | KMT2A (0.36) | KMT2AALDH1A1 | |
| SCHEMBL8635463 | 0.85 | AKR1C3 (0.45) | KMT2AMEN1MAPTALDH1A1TDP1 | |
| SCHEMBL7766569 | 0.84 | SLC9A1 (0.56) | — | |
| SCHEMBL8635252 | 0.81 | AKR1C3 (0.50) | NPC1PDE4BKMT2AMEN1LMNA | |
| SCHEMBL8632908 | 0.80 | PTGS1 (0.43) | KMT2AMEN1LMNA | |
| SCHEMBL8631102 | 0.79 | AKR1C3 (0.47) | KMT2AMEN1LMNAMAPTALDH1A1 | |
| SCHEMBL8634301 | 0.79 | SLC9A1 (0.36) | ALDH1A1 | |
| SCHEMBL8637536 | 0.78 | AKR1C3 (0.51) | NPC1PDE4BKMT2AMEN1LMNA | |
| SCHEMBL8633408 | 0.78 | ALDH1A1 (0.39) | NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1057999-C | 4-Aminobenzoylguanidine derivatives | MERCK PATENT GMBH (DE) | 2000-11-01 | — | — | CN | disclosed |
| US-5739142-A | 4-aminobenzoylguanidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-04-14 | — | — | US | disclosed |
| CN-1138575-A | 4-aminobenzoylguanidine derivatives | MERCK PATENT GMBH (DE) | 1996-12-25 | — | — | CN | disclosed |