SCHEMBL8635855

SCHEMBL8635855

[NH]c1nc(F)c(F)c(Cl)n1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8581211 0.72
SCHEMBL5635013 0.72 ALDH1A1 (0.39)
SCHEMBL4048252 0.69
SCHEMBL8635860 0.67 CYP1A2 (0.30)
SCHEMBL10744210 0.65
SCHEMBL8800638 0.65 PDE10A (0.31)
SCHEMBL2088817 0.64 KEAP1 (0.32)
SCHEMBL9194408 0.64 CYP1A2 (0.42)
SCHEMBL10620477 0.61
SCHEMBL7028015 0.61 MEN1 (0.36)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5496707-A Assay method for hemicellulases using a colored substrate CIBA-GEIGY CORPORATION (US) 1996-03-05 US claimed
EP-0882098-A1 DYES CONTAINING A 2,4,5-TRIFLUORO-3,6-DICYANOPHENYL REACTIVE GROUP AND USE THEREOF BASF AKTIENGESELLSCHAFT (DE) 1998-12-09 EP disclosed
US-5759247-A COLORING PAPER, PLASTICS, TEXTILES ZENECA LIMITED (GB) 1998-06-02 US disclosed
WO-1997027250-A1 DYES CONTAINING A 2,4,5-TRIFLUORO-3,6-DICYANOPHENYL REACTIVE GROUP AND USE THEREOF BASF AKTIENGESELLSCHAFT (DE) 1997-07-31 WO disclosed
US-5496707-A Assay method for hemicellulases using a colored substrate CIBA-GEIGY CORPORATION (US) 1996-03-05 US disclosed
US-5451666-A Reactive dyes having a triazine group which is substituted by hydrogen or an alkyl group ZENECA LIMITED (GB) 1995-09-19 US disclosed
US-5373094-A Reactive dyes containing a 2,6-difluoro-3,5-dichloropyridine group ZENECA LIMITED (GB) 1994-12-13 US disclosed
US-5359043-A Reactive dyes having a sulphonamido group ZENECA LIMITED (GB) 1994-10-25 US disclosed
EP-0578357-A1 Water soluble reactive dyes ZENECA LIMITED (GB) 1994-01-12 EP disclosed
EP-0576143-A2 Reactive dyes containing a 2,6-difluoro-3,5-dichloropyridine-4-ylamino group ZENECA LIMITED (GB) 1993-12-29 EP disclosed
EP-0514001-A1 Reactive dyes ZENECA LIMITED (GB) 1992-11-19 EP disclosed